Organocatalytic asymmetric direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to nitroolefins
Organocatalytic asymmetric direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to nitroolefins
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DOI：
10.1039/c2ob25832c
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Mukherjee, Santanu
中科院分区：
文献类型：
--
作者：
Choudhury, Abhijnan Ray;Mukherjee, Santanu
使用金鸡纳生物碱作为催化剂，开发了第一个由α，β-不饱和γ-丁内酰胺合成硝基烯烃的有机催化对映选择性直接插烯迈克尔反应。两种产物对映异构体都是可获得的，具有中等至良好的对映选择性。
The first organocatalytic enantioselective direct vinylogous Michael reaction of alpha,beta-unsaturated gamma-butyrolactam to nitroolefins is developed using cinchona alkaloids as the catalysts. Both product enantiomers are accessible with moderate to good enantioselectivity.