Cutaneous malignant melanoma in children and adolescents in Sweden, 1993-2002: The increasing trend is broken
Cutaneous malignant melanoma in children and adolescents in Sweden, 1993-2002: The increasing trend is broken
复制标题
DOI：
10.1002/ijc.22692
复制
发表时间：
2007-07-15
影响因子：
6.4
通讯作者：
Fredrikson, Mats
中科院分区：
文献类型：
--
作者：
Karlsson, Pia M.;Fredrikson, Mats
1973年至1992年，瑞典青少年皮肤恶性黑色素瘤的发病率迅速上升，而年幼儿童的发病率仍然很低。为了研究这一年轻人群中黑色素瘤的进一步趋势和特征，对1993-2002年间瑞典癌症登记处报告的20岁以下所有病例的数据和相应的病理报告进行了检查。向登记处报告的案件有79起。男24例，女55例。大多数黑色素瘤发生在躯干，其次是腿部，无论男女。肿瘤厚度中位数为0.8 mm。15岁以下儿童的黑色素瘤比15-19岁的儿童更重。浅表播散性黑色素瘤是最常见的组织学亚型(43/78，55%)。黑色素瘤特异性5年生存率为90%。1993-2002年，年龄标化发病率从1983-1992年的5.0/百万下降到3.6/百万(相对危险度0.74，95%可信区间0.58-0.92)。最明显的下降是男孩躯干上的黑色素瘤和女孩腿上的黑色素瘤。在1968年至1972年出生的人群中，15-19岁男孩的发病率达到顶峰，在1973年至1977年期间出生的女孩达到高峰。发病率的下降可能是旨在减少儿童时期阳光暴露的公共卫生运动的结果。较深肤色和较低黑色素瘤风险的个体移民增加可能会产生有益的影响。(C)2007年Wiley-Liss，Inc.
The incidence of cutaneous malignant melanoma rose rapidly in teenagers in Sweden during 1973-1992, while it remained low in younger children. To study the further trends and characteristics of melanoma in this young population, data on all cases in individuals under 20 years of age reported to the Swedish Cancer Registry during 1993-2002, and the corresponding pathology reports were examined. Seventy-nine cases were reported to the Registry. There were 24 males and 55 females. Most melanomas occurred on the trunk followed by the legs in both genders. The median tumor thickness was 0.8 mm. Children under age 15 had thicker melanomas than individuals aged 15-19. Superficial spreading melanoma was the most common histological subtype (43/78, 55%). The melanoma-specific 5-year survival rate was 90%. During 1993-2002, the age-standardized incidence fell to 3.6/million from 5.0/million in 1983-1992 (RR 0.74, 95% CI 0.58-0.92). The most pronounced decrease was for melanomas on the trunk in boys and on the legs in girls. The incidence for 15-19-year-old boys peaked for the cohort born between 1968 and 1972 and for girls between 1973 and 1977. The decrease in incidence may be a result of public health campaigns aiming at reducing sun exposure in childhood. A contributing effect from an increased immigration of individuals with darker complexions and at a lower melanoma risk is probable. (C) 2007 Wiley-Liss, Inc.