Autophagy in Cardiovascular Aging
Autophagy in Cardiovascular Aging
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DOI：
10.1161/circresaha.118.312208
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发表时间：
2018-09-14
影响因子：
20.1
通讯作者：
Kroemer, Guido
中科院分区：
文献类型：
--
作者：
Abdellatif, Mahmoud;Sedej, Simon;Kroemer, Guido
心血管疾病是老龄化社会最突出的疾病。事实上，衰老促进了心脏和血液循环系统的结构和功能衰退。在这篇综述中，我们修改了已知的长寿途径对心血管健康的贡献，并描述了干扰它们的可能性。特别是，我们评估自噬，细胞内的分解代谢循环系统与生命和健康寿命的延长。我们目前的遗传模型，药物干预，饮食策略，阻止，减少或增强自噬后，年龄相关的心血管恶化。热量限制或热量限制模拟物，如二甲双胍，亚精胺和雷帕霉素（所有这些都会触发自噬）是衰老过程中最有希望的心脏保护干预措施之一。我们的结论是，自噬是一个基本的过程，以确保心脏和血管的健康，在老龄化和概述其公认的治疗重要性。
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life - and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.