BNCT for advanced or recurrent head and neck cancer
BNCT for advanced or recurrent head and neck cancer
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DOI：
10.1016/j.apradiso.2014.04.007
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发表时间：
2014-06-01
影响因子：
1.6
通讯作者：
Harada, Tamotsu
中科院分区：
文献类型：
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作者：
Aihara, Teruhito;Morita, Norimasa;Harada, Tamotsu
头颈部复发性鳞状细胞癌（SCC）和局部晚期非鳞状细胞癌伴恶性黑色素瘤（non-SCC）患者，手术和/或常规放化疗联合治疗的疗效有限。目前，一些研究机构正在进行BNCT治疗头颈部肿瘤的临床试验，以验证其有效性。2003年10月至2007年9月，我院对10例复发性鳞状细胞癌、7例复发性非鳞状细胞癌和3例新诊断的非鳞状细胞癌患者进行了BNCT检查。11例完全缓解，7例部分缓解。有效率[（CR+PR）/总例数]为90%。在任何患者中均未观察到严重的急性或慢性正常组织反应。BNCT在复发性SCC和局部晚期非SCC患者中有效且安全（C）2014 Elsevier Ltd.保留所有权利。
The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC (C) 2014 Elsevier Ltd. All rights reserved.