Unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus clone in a geographic area of low incidence
Unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus clone in a geographic area of low incidence
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DOI：
10.1086/313522
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发表时间：
1999-12-01
影响因子：
11.8
通讯作者：
Francioli, P
中科院分区：
文献类型：
--
作者：
Blanc, DS;Petignat, C;Francioli, P
我们描述了一种青霉素敏感的耐甲氧西林金黄色葡萄球菌（MRSA）克隆在瑞士西部医院的不寻常传播，那里的MRSA发病率通常很低。在两年的时间里，该克隆体导致了几次暴发，并从21个机构的156人中分离出来。脉冲场凝胶电泳（PFGE）分型结果表明，所有分离株均为同一克隆。在其中一起涉及30例病例的疫情中，克隆人至少造成了17例继发病例。相比之下，在后一次爆发期间，PFGE评估的其他9名携带不同MRSA菌株的患者在同一病房住院，但没有发生继发病例。这些观察结果表明，与其他MRSA菌株相比，该克隆具有一些内在因素，有助于其传播能力，因此可以被认为是流行性的。
We describe the unusual spread of a penicillin-susceptible methicillin-resistant Staphylococcus aureus (MRSA) clone in hospitals in western Switzerland, where the incidence of MRSA is usually low. During a 2-year period, this clone had been responsible for several outbreaks and had been isolated from >156 persons in 21 institutions. Molecular typing by pulsed-field gel electrophoresis (PFGE) demonstrated that all of these isolates belonged to he same clone. In 1 of the outbreaks, involving 30 cases, the clone was responsible for at least 17 secondary cases. In contrast, during the period of the latter outbreak, 9 other patients harboring different MRSA strains, as assessed by PFGE, were hospitalized in the same wards, but no secondary cases occurred. These observations suggest that this clone, compared with other MRSA strains, had some intrinsic factor(s) that contributed to its ability to disseminate and could thus be considered epidemic.