A refined method for the meta-analysis of controlled clinical trials with binary outcome
A refined method for the meta-analysis of controlled clinical trials with binary outcome
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DOI：
10.1002/sim.1009
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发表时间：
2001-12-30
影响因子：
2
通讯作者：
Knapp, G
中科院分区：
文献类型：
--
作者：
Hartung, J;Knapp, G
针对具有二元结局的临床对照试验的荟萃分析，提出了一种检验总体疗效的检验统计量，该统计量基于荟萃分析随机效应模型中常用的疗效估计量方差的精细估计量。在模拟研究中，它表明，所提出的测试保持规定的显着性水平！分别比固定效应和随机效应模型中常用的检验好得多。此外，在使用检验时，没有必要事先在固定效应和随机效应方法之间进行选择。所提出的方法以相同的方式适用于对照多中心研究的分析，具有二元结果，包括药物和中心之间可能的相互作用。版权所有（C）2001约翰威利父子有限公司
For the meta-analysis of controlled clinical trials with binary outcome a test statistic for testing an overall treatment effect is proposed, which is based on a refined estimator for the variance of the treatment effect estimator usually used in the random-effects model of meta-analysis. In simulation studies it is shown that the proposed test keeps the prescribed significance level! much better than the commonly used tests in the fixed-effects and random-effects model, respectively. Moreover, when using the test it is not necessary to choose between fixed effects and random effects approaches in advance. The proposed method applies in the same way to the analysis of a controlled multi-centre study, with binary outcome, including a possible interaction between drugs and centres. Copyright (C) 2001 John Wiley & Sons, Ltd.