Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis.
Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis.
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基质金属蛋白酶 3 基因多态性与类风湿性关节炎易感性缺乏关联：荟萃分析
DOI：
10.1186/1471-2474-15-376
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发表时间：
2014-11-18
影响因子：
2.3
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Feng Z;He G;Chen Z;Wu Z;Li J
流行病学研究调查了基质金属蛋白酶-3（MMP-3）基因1171 5A/6A多态性与类风湿关节炎（RA）的关系，但结果不一致。为了评估具体的关系，我们进行了荟萃分析来澄清争议。方法从PubMed、EMBASE和中国知网数据库中检索至2013年12月7日的相关文献。获得了MMP-3的等位基因数量和基因型。采用比值比（ORs）和95%置信区间（CIs）估计MMP-3 5A/6A启动子多态性与RA之间的关系。所有统计分析均采用STATA11.0软件进行。结果最终meta分析共纳入6项病例对照研究，共1451例病例和1239例对照。在所有遗传模型中，MMP-3 5A/6A启动子多态性与RA无显著相关性（6A与5A: OR = 1.19, 95% CI = 0.91-1.56，P= 0.203； 5A/6A与5A/5A: OR = 1.31, 95% CI = 0.89-1.92，P= 0.174； 6A/6A与5A/5A: OR = 1.78, 95% CI = 0.68-4.61，P= 0.238；隐性模型：OR = 1.48, 95% CI = 0.88-2.47，P= 0.141；显性模型：OR = 1.46, 95% CI = 0.71-3.00，P= 0.299）。在种族亚组分析中，我们得到了类似的结果。结论系统研究了MMP-3-1171 5A/6A多态性与RA易感性的关系；然而，结果显示缺乏相关性。考虑到部分研究样本量较小且存在选择偏倚，需要进一步的研究来证实研究结果。
BackgroundEpidemiological studies have investigated the association between matrix metalloproteinase-3(MMP-3) gene-1171 5A/6A polymorphism and rheumatoid arthritis (RA), but the results were inconsistent. To evaluate the specific relationship, we performed a meta-analysis to clarify the controversies.MethodsThe relevant literatures dated to December 07th 2013 were retrieved from PubMed, EMBASE and the China National knowledge Infrastructure (CNKI) databases. The number of the alleles and genotypes for MMP-3 were obtained. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP-3 5A/6A promoter polymorphism and RA. All of the statistical analyses were conducted by STATA11.0 software.ResultsA total of 6 case-control studies covering 1451 cases and 1239 controls were included in the final meta-analysis. There was no significant association between MMP-3 5A/6A promoter polymorphism and RA in all genetic models (for 6A versus 5A: OR = 1.19, 95% CI = 0.91-1.56,P= 0.203; 5A/6A versus 5A/5A: OR = 1.31, 95% CI = 0.89-1.92,P= 0.174; 6A/6A versus 5A/5A: OR = 1.78, 95% CI = 0.68-4.61,P= 0.238; the recessive model: OR = 1.48, 95% CI = 0.88-2.47,P= 0.141; and the dominant model: OR = 1.46, 95% CI = 0.71-3.00,P= 0.299). In the subgroup analysis by ethnicity, we obtained the similar results.ConclusionsWe systematically investigate the association between MMP-3-1171 5A/6A polymorphism and RA susceptibility; however, the results show a lack of correlation. Considering the small sample size and the selection bias existed in some studies, further studies are needed to confirm the findings.
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影响因子：
4.9
作者：
Dörr S;Lechtenböhmer N;Rau R;Herborn G;Wagner U;Müller-Myhsok B;Hansmann I;Keyszer G
通讯作者：
Keyszer G
影响因子：
5.5
作者：
Tsukahara, S.;Shinozaki, M.;Momohara, S.
通讯作者：
Momohara, S.
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG
影响因子：
5
作者：
Mattey, DL;Nixon, NB;Hajeer, AH
通讯作者：
Hajeer, AH
影响因子：
1.4
作者：
Abd-Allah, Somia H.;Shalaby, Sally M.;Abou El-Saoud, Amany M.
通讯作者：
Abou El-Saoud, Amany M.