Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications
Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications
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DOI：
10.1016/j.carbpol.2009.12.024
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发表时间：
2010-05-05
影响因子：
11.2
通讯作者：
Jayakumar, R.
中科院分区：
文献类型：
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作者：
Kumar, P. T. Sudheesh;Abhilash, S.;Jayakumar, R.
我们使用β-吉他蛋白锡水凝胶与银纳米颗粒开发了用于伤口愈合应用的新型β-胆素/纳米胶质蛋白/纳米胶体复合支架。使用SEM，FT-IR，XRD和TGA研究对制备的纳米粒细胞颗粒和纳米复合材料支架进行了表征。评估了制备的复合支架的抗菌，肿胀，细胞附着和细胞毒性研究。制备的β-吉他蛋白/纳米胶体复合材料支架是针对大肠杆菌和金黄色葡萄球菌的杀菌性，并且表现出良好的血液闭合能力。使用否决（上皮）细胞的细胞附着研究表明，这些细胞已很好地附着在支架上。这些结果表明，β-吉他蛋白/纳米胶体复合支架可能是伤口敷料应用的有前途的候选人。 （c）2009 Elsevier Ltd.保留所有权利。
We developed novel beta-chitin/nanosilver composite scaffolds for wound healing applications using beta-chitin tin hydrogel with silver nanoparticles. The prepared nanosilver particles and nanocomposite scaffolds were characterized using SEM, FT-IR, XRD and TGA studies. The antibacterial, blood-clotting, swelling, cell attachment and cytotoxicity studies of the prepared composite scaffolds were evaluated. The prepared beta-chitin/nanosilver composite scaffolds were bactericidal against Escherichia coli and Staphylococcus aureus and it showed good blood-clotting ability as well. Cell attachment studies using veto (epithelial) cells showed that the cells were well attached on the scaffolds. These results suggested that beta-chitin/nanosilver composite scaffold could be a promising candidate for wound dressing applications. (C) 2009 Elsevier Ltd. All rights reserved.