Prognostic factors for relapse in stage I seminoma managed with surveillance: A validation study.
Prognostic factors for relapse in stage I seminoma managed with surveillance: A validation study.
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通过监测管理的 I 期精原细胞瘤复发的预后因素：一项验证研究。
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
P. Warde
中科院分区：
文献类型：
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作者：
P. Chung;G. Daugaard;S. Tyldesley;T. Panzarella;C. Kollmannsberger;M. Gospodarowicz;P. Warde
4535背景：单用睾丸切除术治疗I期睾丸癌的预后模型预测价值有限，因为高危组的复发率仅为30%。虽然该模型尚未在独立的数据集上得到验证，但它已被广泛应用于治疗策略中。我们在过去十年中通过监测管理的连续系列患者中测试了该模型的价值。研究方法：回顾性分析了1998年至2005年间在哥本哈根国立医院、玛格丽特公主医院和不列颠哥伦比亚省癌症机构接受监测的687例I期肺癌患者的个人资料。分析了诊断时年龄、原始病理[肿瘤大小、组织学亚型、睾丸网侵犯、睾丸水肿、睾丸外软组织、精索、图尼卡白蛋白和小血管侵犯（SVI）]对复发的预后重要性的影响。该分析受限于大量报告中的缺失数据[睾丸网（33%），SVI（25%），肿瘤大小2......
4535 Background: A prognostic model for stage I seminoma managed by orchiectomy alone has limited predictive value since the high risk group has only a 30% relapse rate. Although the model has not been validated in an independent data set, it has been applied widely in treatment policies. We tested the value of the model in a consecutive series of patients managed by surveillance in the past decade. Methods: Individual data on 687 stage I seminoma patients managed by surveillance between 1998 and 2005 at the Copenhagen National Hospital, Princess Margaret Hospital and British Columbia Cancer Agency was retrospectively analyzed. Impact of age at diagnosis, original pathology [tumor size, histologic subtype, rete testis invasion, epidydimis, extratesticular soft tissue, spermatic cord, tunica albuginea, and small vessel invasion (SVI)] were analyzed for prognostic importance for relapse. The analysis was limited by missing data in significant proportion of reports [rete testis (33%), SVI (25%), tumor size 2...