Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor
Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor
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DOI：
10.1016/j.celrep.2017.09.095
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发表时间：
2017-10-24
期刊：
影响因子：
8.8
通讯作者：
Do, Michael Tri H.
中科院分区：
文献类型：
--
作者：
Emanuel, Alan J.;Kapur, Kush;Do, Michael Tri H.
M1型的视网膜内光敏神经节细胞编码环境辐照度，用于包括昼夜节律和瞳孔调节在内的功能。它们独特的作用、形态和分子标记表明它们是定型的电路元件，但它们的生理均匀性尚未以系统的方式进行研究。我们已经分析了小鼠M1的生物物理参数，发现极端变化是它们的标志。大多数参数跨度为1-3个对数单位，并且在M1中，支配不同功能的大脑区域的整个范围是明显的。具有相似形态的细胞之间和相邻的M1 s之间同时记录的生物物理剖面不同。每个参数的变化在很大程度上独立于其他参数，允许灵活的个性化。因此，共同的刺激驱动跨单元的异质尖峰输出。相比之下，在类似条件下，定向选择性视网膜神经节细胞的群体在生理上是均匀的。因此，M1缺乏生物物理恒定性，并向下游发送不同的信号。
Intrinsically photosensitive retinal ganglion cells of the M1 type encode environmental irradiance for functions that include circadian and pupillary regulation. Their distinct role, morphology, and molecular markers indicate that they are stereotyped circuit elements, but their physiological uniformity has not been investigated in a systematic fashion. We have profiled the biophysical parameters of mouse M1s and found that extreme variation is their hallmark. Most parameters span 1-3 log units, and the full range is evident in M1s that innervate brain regions serving divergent functions. Biophysical profiles differ among cells possessing similar morphology and between neighboring M1s recorded simultaneously. Variation in each parameter is largely independent of that in others, allowing for flexible individualization. Accordingly, a common stimulus drives heterogeneous spike outputs across cells. By contrast, a population of directionally selective retinal ganglion cells appeared physiologically uniform under similar conditions. Thus, M1s lack biophysical constancy and send diverse signals downstream.