Deep brain stimulation of the internal globus pallidus for refractory tardive dystonia
Deep brain stimulation of the internal globus pallidus for refractory tardive dystonia
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DOI：
10.1016/j.parkreldis.2006.11.007
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Splegelmann, Roberto
中科院分区：
文献类型：
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作者：
Cohen, Oren S.;Hassin-Baer, Sharon;Splegelmann, Roberto
我们报告了一个快速，戏剧性和持续的改善后，双边苍白球刺激两名患者的顽固性全身迟发性肌张力障碍。这两名患者都有慢性精神疾病，尽管长期停用抗精神病药和所有可用的对症治疗，但仍出现慢性致残性全身性肌张力障碍症状。在13个月和7个月的随访期内，两例患者的临床获益持续存在。我们的两名患者的良好和长期的反应表明，脑深部电刺激可能是一种有效的治疗医学难治性迟发性肌张力障碍。(c)2006爱思唯尔有限公司保留所有权利。
We report a rapid, dramatic and sustained improvement following bilateral pallidal stimulation in two patients affected by intractable generalized tardive dystonia. Both patients had a chronic psychiatric disorder and developed chronic disabling generalized dystonic symptoms persisting despite prolonged withdrawal of neuroleptics and all available symptomatic treatment. The clinical benefit in both patients persisted throughout all the follow up period of 13 and 7 months. The favorable and prolonged response in our two patients suggests that deep brain stimulation may be an effective treatment for medically refractory tardive dystonia. (c) 2006 Elsevier Ltd. All rights reserved.