SERIAL GADOLINIUM ENHANCED MAGNETIC-RESONANCE IMAGING IN MULTIPLE-SCLEROSIS
SERIAL GADOLINIUM ENHANCED MAGNETIC-RESONANCE IMAGING IN MULTIPLE-SCLEROSIS
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DOI：
10.1093/brain/111.4.927
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发表时间：
1988-08-01
期刊：
影响因子：
14.5
通讯作者：
MCDONALD, WI
中科院分区：
文献类型：
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作者：
MILLER, DH;RUDGE, P;MCDONALD, WI
对9例多发性硬化（MS）患者进行了Gd-DTPA（Gd-DTPA）增强磁共振成像（MRI）检查。7例首次扫描均见强化灶，均为急性复发。大多数增强病灶无症状。在第二次扫描（3 - 5周后），仅在第一次扫描时增强的54个病灶中的12个中观察到持续增强。第三次扫描（6个月后）无病变显示持续增强。在第二次平扫时，所有12个新病灶区域均出现增强，在第三次平扫时，15个新病灶中有8个出现增强。在4个早期扫描无增强的较老病灶中也观察到增强。弛豫时间测量表明，在一些nonehancing病变，这可能是由于一个微妙的血脑屏障干扰没有检测到Gd-DTPA的高含水量。结果表明，血脑屏障损伤是MRI检测到的新MS病变的一致发现。Gd-DTPA是一个有用的标记物，新的和生物活性病变，并应证明在监测MS的治疗试验的价值。
Serial gadoliniun-DTPA (Gd-DTPA) enhanced magnetic resonance imaging (MRI) was performed in 9 patients with multiple sclerosis (MS). On the first scan enhancing lesions were seen in 7 patients, all of whom were in acute relapse. Most enhancing lesions were asymptomatic. On the second scan (3 to 5 weeks later), persisting enhancement was seen in only 12/54 lesions which enhanced on the first scan. No lesion showed persisting enhancement on the third scan (after 6 months). Enhancement occurred in all 12 new lesion areas seen on the unenhanced second scan and in 8 of 15 new lesions seen on the third scan. Enhancement was also seen in 4 older lesions which had been nonenhancing on earlier scans. Relaxation time measurements demonstrated a high water content in some nonehancing lesions, which could be due to a subtle blood-brain barrier disturbance not detected with Gd-DTPA. The results show that blood-brain barrier impairment is a consistent finding in new MS lesions detected with MRI. Gd-DTPA is a useful marker of new and biologically active lesions and should prove of value in monitoring therapeutic trials in MS.