NF-Y in invertebrates.
NF-Y in invertebrates.
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DOI：
10.1016/j.bbagrm.2016.10.008
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
M. Yamaguchi;Md. Saheb Ali;Y. Yoshioka;Luong Linh Ly;H. Yoshida
中科院分区：
文献类型：
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作者：
M. Yamaguchi;Md. Saheb Ali;Y. Yoshioka;Luong Linh Ly;H. Yoshida
果蝇（Drosophila melanogaster）和秀丽隐杆线虫（C. habditiselegans）均能在一定程度上抑制果蝇的生长。果蝇（DrosophilaNF-Y，dNF-YB）是研究NF-Y在发育过程中的作用的重要模式生物，它由dNF-YA、dNF-YB和dNF-YC三个亚基组成。在某些组织中，dNF-YC相关蛋白Mes 4可能取代dNF-YC形成dNF-Y复合物。对眼成虫盘特异性dNF-Y敲除果蝇的研究显示，dNF-Y正调控编码受体酪氨酸激酶的基因，ERK途径的一个组成部分，负调控编码转录因子的Sensless基因，以确保R7感光细胞的正常发育以及R7轴突的正确靶向。dNF-Y还控制果蝇Bcl-2（debcl）调节细胞凋亡。在果蝇胸部发育过程中，dNF-Y对果蝇JNK（basket）的正常表达和JNK信号通路的活性都是必需的，果蝇p53基因也被确定为dNF-Y的靶基因之一。elegans含有两种形式的NF-YA亚基CeNF-YA 1和CeNF-YA 2。因此，elegansNF-Y（CeNF-Y）由CeNF-YB、CeNF-YC和CeNF-YA 1或CeNF-YA 2组成。CeNF-Y负调节参与尾部图案形成的Hoxgeneegl-5（果蝇Abdominal-B的直系同源物）的表达。CeNF-Y还负调节thetbx-2基因的表达，该基因对于咽肌的发育、神经细胞命运的特化和嗅觉神经元的适应是必需的。CeNF-Y对fegl-5和tbx-2表达的负调控为NF-Y在发育过程中负调控基因表达的生理意义提供了新的见解。此外，还对NF-Y在扁形动物中的研究进行了综述。这篇文章是特刊的一部分，题为：核因子Y在发展和疾病中，由Roberto Mantovani教授编辑。
BothDrosophila melanogasterandCaenorhabditis elegans(C. elegans) are useful model organisms to studyin vivoroles of NF-Y during development.DrosophilaNF-Y (dNF-Y) consists of three subunits dNF-YA, dNF-YB and dNF-YC. In some tissues, dNF-YC-related protein Mes4 may replace dNF-YC in dNF-Y complex. Studies with eye imaginal disc-specific dNF-Y-knockdown flies revealed that dNF-Y positively regulates thesevenlessgene encoding a receptor tyrosine kinase, a component of the ERK pathway and negatively regulates theSenslessgene encoding a transcription factor to ensure proper development of R7 photoreceptor cells together with proper R7 axon targeting. dNF-Y also controls theDrosophila Bcl-2(debcl) to regulate apoptosis. In thorax development, dNF-Y is necessary for both properDrosophila JNK(basket) expression and JNK signaling activity that is responsible for thorax development.Drosophila p53gene was also identified as one of the dNF-Y target genes in this system.C. eleganscontains two forms of NF-YA subunit, CeNF-YA1 and CeNF-YA2.C. elegansNF-Y (CeNF-Y) therefore consists of CeNF-YB, CeNF-YC and either CeNF-YA1 or CeNF-YA2. CeNF-Y negatively regulates expression of theHoxgeneegl-5(ortholog ofDrosophila Abdominal-B) that is involved in tail patterning. CeNF-Y also negatively regulates expression of thetbx-2gene that is essential for development of the pharyngeal muscles, specification of neural cell fate and adaptation in olfactory neurons. Negative regulation of the expression ofegl-5andtbx-2by CeNF-Y provides new insight into the physiological meaning of negative regulation of gene expression by NF-Y during development. In addition, studies on NF-Y in platyhelminths are also summarized. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.