Use of the herpes amplicon system as a vehicle for somatic gene transfer.
Use of the herpes amplicon system as a vehicle for somatic gene transfer.
复制标题
使用疱疹扩增子系统作为体细胞基因转移的载体。
DOI：
10.1016/s0169-409x(97)00020-3
复制
发表时间：
1997
影响因子：
16.1
通讯作者：
Brooks,AI
中科院分区：
文献类型：
--
作者：
Federoff,HJ;Halterman,MW;Brooks,AI
疱疹病毒生物学的研究已经产生了两种载体传递策略，它们利用了这类病毒所表现出的高度进化的神经元趋向性和生命周期调节。扩增子和重组单纯疱疹病毒系统有望用于基因转移到神经系统，尽管迄今为止这两种载体都尚未用于临床试验，但它们在基因传递和神经元生理扰动方面的应用已经得到了很好的证实。我们将回顾疱疹扩增子系统的性质，并展示其在神经科学应用中的效用。
The study of herpes virus biology has produced two vector delivery strategies which exploit the highly evolved neuronal tropism and life cycle regulation exhibited by this class of viruses. Amplicon and recombinant herpes simplex virus systems show promise for use in gene transfer to the nervous system and although neither vector has been used in clinical trials to date, their application to gene delivery and perturbation of neuronal physiology have been well established. We will review the properties of the herpes amplicon system, and demonstrate its utility in neuroscience applications.