The missing data problem in birth weight percentiles and thresholds for "Small-for-Gestational-Age"
The missing data problem in birth weight percentiles and thresholds for "Small-for-Gestational-Age"
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DOI：
10.1093/aje/kwm327
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发表时间：
2008-04-01
影响因子：
5
通讯作者：
Platt, Robert W.
中科院分区：
文献类型：
--
作者：
Hutcheon, Jennifer A.;Platt, Robert W.
基于给定胎龄的活产分布的胎龄体重图表和“小于胎龄”的定义通常用于识别胎儿生长不良的婴儿。然而，基于仅活产体重的参考文献在早产年龄时存在严重缺陷，因为缺失了仍在子宫内的胎儿体重数据，这些缺失的数据给胎儿生长受限的病因学研究带来了相当大的偏倚。应用标准流行病学方法缺失数据，以帮助产生围产期体重指数，提供无偏见的评估胎儿生长和小于胎龄儿的风险。
Weight-for-gestational-age charts and definitions of "small-for-gestational-age" based on the distribution of livebirths at a given gestational age have conventionally been used to identify infants whose fetal growth is poor. However, references based on the weights of only livebirths have serious shortcomings at preterm ages due to missing data on the weights of fetuses still in utero, and these missing data introduce considerable bias to etiologic studies of fetal growth restriction. Application of standard epidemiologic approaches for missing data is needed to help produce perinatal weight percentiles that provide unbiased assessment of fetal growth and risks of small-for-gestational-age.