Improving the Procedure for Detection of Intrahepatic Transplanted Islets by Magnetic Resonance Imaging
Improving the Procedure for Detection of Intrahepatic Transplanted Islets by Magnetic Resonance Imaging
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DOI：
10.1111/j.1600-6143.2009.02791.x
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发表时间：
2009-10-01
影响因子：
8.8
通讯作者：
Del Maschio, A.
中科院分区：
文献类型：
--
作者：
Malosio, M. L.;Esposito, A.;Del Maschio, A.
胰岛移植是1型糖尿病患者恢复正常血糖的有效治疗方法，但只有少数病例能获得长期的胰岛移植功能。胰岛的非侵入性磁共振成像是一个有吸引力的选择，“实时”监测移植物的演变。到目前为止，之前的研究是在没有标准化标记程序的情况下进行的，除了在患者中进行可行性研究外，仅使用高场磁体（4.7 T）测试了各种标记方法的有效性和安全性。在这项研究中，我们解决了：（a）标准化的标记程序，人类胰岛与临床批准的造影剂Endorem
Islet transplantation is an effective therapy for restoring normoglycemia in type-1 diabetes, but long-term islet graft function is achieved only in a minority of cases. Noninvasive magnetic resonance imaging of pancreatic islets is an attractive option for "real-time" monitoring of graft evolution. So far, previous studies have been performed in the absence of a standardized labeling procedure and, besides a feasibility study in patients, the effectiveness and safety of various labeling approaches were tested only with high field magnets (4.7 T). In this study, we addressed: (a) standardization of a labeling procedure for human islets with clinically-approved contrast agent Endorem