G72/G30 (DAOA) and Juvenile-Onset Mood Disorders
G72/G30 (DAOA) and Juvenile-Onset Mood Disorders
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DOI：
10.1002/ajmg.b.30904
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发表时间：
2009-10-05
影响因子：
2.8
通讯作者：
Barr, Cathy L.
中科院分区：
文献类型：
--
作者：
Gomez, Lissette;Wigg, Karen;Barr, Cathy L.
染色体13q区域在许多基因组扫描和集中的连锁研究中与双相情感障碍有关。此前，我们在对146名匈牙利青少年发病情绪障碍兄弟姐妹家庭的基因组扫描中发现了与13q32区域的联系。在这个区域内有重叠的基因G72/G30，其中G72现在正式命名为d -氨基酸氧化酶激活剂（DAOA）。这个位点与恐慌症、精神分裂症和双相情感障碍有关。在这项研究中，我们在646个核心家庭的样本中检测了这些基因中的I - I标记与情绪障碍的关联，这些核心家庭的样本被确定为14.9岁之前患有情绪障碍的先证者。我们发现了与该基因中的三个标记（rs2391191, rs3918341, rs1935062）相关的证据，其中两个在先前的研究中与双相情感障碍有关。当校正了测试标记的数量后，结果不再显著，然而，先前在多项研究中有关该基因的证据表明，该基因是青少年发病情绪障碍的潜在因素。(C) 2008 Wiley-Liss, Inc。
The chromosome 13q region has been linked to bipolar disorder in a number of genome scans as well as focused linkage studies. Previously we identified linkage to the 13q32 region in a genome scan of 146 affected sibling pair families from Hungary with juvenile-onset mood disorders. Within this region are the overlapping genes G72/G30, with G72 now officially named as D-amino-acid oxidase activator (DAOA). This locus has been associated with panic disorder, schizophrenia, and bipolar disorder. In this study, we tested for association to I I markers in these genes and mood disorders in a sample of 646 nuclear families identified with a proband with onset of a mood disorder before 14.9 years of age. We identified evidence for association to three markers within the gene (rs2391191, rs3918341, rs1935062), two of which had been associated with bipolar disorder in previous studies. When corrected for the number of markers tested, the results were no longer significant, however the prior evidence for association of this gene in multiple studies points to this gene as a potential contributor to juvenile-onset mood disorders. (C) 2008 Wiley-Liss, Inc.