Electrosynthesis of Phosphacycles via Dehydrogenative C-P Bond Formation Using DABCO as a Mediator
Electrosynthesis of Phosphacycles via Dehydrogenative C-P Bond Formation Using DABCO as a Mediator
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DOI：
10.1021/acs.orglett.1c00807
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发表时间：
2021-04-05
期刊：
影响因子：
5.2
通讯作者：
Suga, Seiji
中科院分区：
文献类型：
--
作者：
Kurimoto, Yuji;Yamashita, Jun;Suga, Seiji
在温和的条件下，首次实现了二芳基磷氧化物（DPOs）的电化学合成。实际方案采用市售且价格低廉的DABCO作为氢原子转移（HAT）介质，导致各种DPOs在中等到良好的产量。该方法也可应用于六元磷环的合成，如苯磷hazine衍生物。机理研究表明，该反应通过电生成的膦基自由基进行。
The first electrochemical synthesis of diarylphosphole oxides (DPOs) was achieved under mild conditions. The practical protocol employs commercially available and inexpensive DABCO as a hydrogen atom transfer (HAT) mediator, leading to various DPOs in moderate to good yields. This procedure can also be applied to the synthesis of six-membered phosphacycles, such as phenophosphazine derivatives. Mechanistic studies suggested that the reaction proceeds via an electro-generated phosphinyl radical.