Real-time optical coherence tomography of the anterior segment at 1310 nm
Real-time optical coherence tomography of the anterior segment at 1310 nm
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DOI：
10.1001/archopht.119.8.1179
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发表时间：
2001-08-01
影响因子：
--
通讯作者：
Izatt, JA
中科院分区：
文献类型：
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作者：
Radhakrishnan, S;Rollins, AM;Izatt, JA
背景：高速扫描技术的最新进展使新一代光学相干层析成像（OCT）系统能够以视频速率进行成像。在这里，一个手持式OCT探头能够成像的眼睛的前段在高帧率首次展示。目的：展示前节段结构的实时OCT成像。设计：调查正常受试者的前段结构。设置:实验室。主要观察指标：实现前段实时成像，图像质量满意，手持式探头方便。结果：使用1310 nm波长的光，以8帧/秒的成像速率对受试者眼睛前段进行光学相干层析成像。影像学检查显示角膜上皮和间质、硬角膜交界处、巩膜、虹膜色素上皮和间质以及前晶状体囊清晰可见。前房角清晰可见。对纤毛体进行了有限的成像。同时进行了光刺激下瞳孔收缩的实时成像。结论：1310nm波长的高速OCT对前节段结构的无创评估具有潜在的应用价值。临床意义：我们的研究结果表明实时OCT在青光眼评估和屈光手术中具有潜在的应用价值。
Background: Recent advances in high-speed scanning technology have enabled a new generation of optical coherence tomographic (OCT) systems to perform imaging at video rate. Here, a handheld OCT probe capable of imaging the anterior segment of the eye at high frame rates is demonstrated for the first time.Objective: To demonstrate real-time OCT imaging of anterior segment structures.Design: Survey of anterior segment structures in normal human subjects.Setting: Laboratory.Main Outcome Measures: Achieving real-time imaging of the anterior segment, satisfactory image quality, and convenience of a handheld probe.Results: Optical coherence tomographic imaging of the anterior segment of the eyes of human subjects was performed using 1310-nm wavelength light with an image rate of 8 frames per second. Imaging trials demonstrated clear resolution of corneal epithelium and stroma, sclerocorneal junction, sclera, iris pigment epithelium and stroma, and anterior lens capsule. The anterior chamber angle was clearly visualized. Limited imaging of the ciliary body was performed. Real-time imaging of pupillary constriction in response to light stimulus was also performed.Conclusion: High-speed OCT at 1310-nm wavelength is a potentially useful technique for noninvasive assessment of anterior segment structures.Clinical Relevance: Our results suggest that realtime OCT has potential applications in glaucoma evaluation and refractive surgery.