Targeted regulation of a lymphocyte-endothelial-interleukin-6 axis by thermal stress
Targeted regulation of a lymphocyte-endothelial-interleukin-6 axis by thermal stress
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DOI：
10.1080/02656730701772498
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Chen, Qing
中科院分区：
文献类型：
--
作者：
Evans, Sharon S.;Fisher, Daniel T.;Chen, Qing
对微生物入侵或恶性进展的免疫保护依赖于淋巴细胞有效穿越全身形态和生化不同的血管部位的能力。淋巴细胞运输到靶组织是由粘附分子和趋化因子协调的，这些分子和趋化因子稳定了循环淋巴细胞和血管内皮细胞之间的动态相互作用。虽然调控淋巴细胞在次级淋巴器官中高内皮小静脉（HEVs）高效迁移的分子机制已经被广泛表征，但关于决定淋巴细胞进入肿瘤组织速率的机制却缺乏可用的信息。本文总结了最近的证据，表明与发热范围热应激相关的炎症信号通过高度调节的淋巴细胞-内皮-白细胞介素-6 （IL-6）生物轴促进淋巴细胞外渗。在基于T细胞的免疫治疗过程中，使用基于热的策略来改善淋巴细胞递送到肿瘤微环境的潜力也将被讨论。
Immune protection from microbial invaders or malignant progression is dependent on the ability of lymphocytes to efficiently traffic across morphologically and biochemically distinct vascular sites throughout the body. Lymphocyte trafficking to target tissues is orchestrated by adhesion molecules and chemokines that stabilize dynamic interactions between circulating lymphocytes and endothelial cells lining blood vessels. While the molecular mechanisms that regulate the efficient migration of lymphocytes across specialized high endothelial venules (HEVs) in secondary lymphoid organs have been extensively characterized, there is a paucity of information available regarding the mechanisms that dictate the rate of lymphocyte entry into tumor tissues. This article summarizes recent evidence that inflammatory cues associated with fever-range thermal stress promote lymphocyte extravasation across HEVs of lymphoid organs through a highly regulated lymphocyte-endothelial-interleukin-6 (IL-6) biological axis. The potential for using thermally-based strategies to improve lymphocyte delivery to the tumor microenvironment during T cell-based immunotherapy will also be discussed.