Age is a Major Pathobiological Determinant of Aortic Dilatation: A Large Autopsy Study of Community Deaths
Age is a Major Pathobiological Determinant of Aortic Dilatation: A Large Autopsy Study of Community Deaths
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DOI：
10.5551/jat.6528
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Ozawa, Toshio
中科院分区：
文献类型：
--
作者：
Sawabe, Motoji;Hamamatsu, Akihiko;Ozawa, Toshio
目的：主动脉扩张是老年人的常见现象。因此，我们的目的是研究主动脉扩张的病理生物学决定因素。研究对象为833例连续尸检的社区死亡病例（男性616例，女性217例）。死亡年龄从20岁到94岁不等，平均59.2岁。我们测量了内周长的主动脉根，弓，下降部分，腹部部分，和分叉在unfixed开放的主动脉在尸检的时间。结果：年龄和主动脉周长之间的简单相关性是最强的下降部分，其次是弓，腹部部分，根，和分叉。下降段的简单相关系数达到0.836（p < 0.001）。随着主动脉粥样硬化严重程度的增加，下降部分的周长显著增加（趋势p < 0.001）。多元回归分析显示年龄、性别和身高与所有五个测量部位的主动脉周长显著相关，而严重动脉粥样硬化与根部、降段和腹部的主动脉周长相关。六个影响因素（年龄、性别、身高、吸烟史、高血压和严重动脉粥样硬化）解释了下降部分周长变异的68.5%;年龄解释57.5%;性别解释8.4%;身高解释1%;严重动脉粥样硬化解释0.8%。动脉粥样硬化对主动脉扩张的贡献非常微弱，不到年龄贡献的七十分之一。主动脉周长，特别是降段，是一个很好的年龄相关指标。
Aim: Aortic dilatation is a well-known phenomenon in the elderly. We therefore aimed to study the pathobiological determinants of aortic dilatation.Methods: Retrospective chart review. The subjects were 833 consecutive autopsy cases (616 men and 217 women) of community deaths. The age at death ranged from 20 to 94 years, with an average of 59.2 years. We measured the internal circumference of the aortic root, arch, descending portion, abdominal portion, and bifurcation in unfixed opened aorta at the time of autopsy.Results: The simple correlation between age and aortic circumference was strongest for the descending portion, followed by the arch, abdominal portion, root, and bifurcation. The simple correlation coefficient reached 0.836 for the descending portion (p < 0.001). The circumference of the descending portion increased significantly as the severity of aortic atherosclerosis increased (p for trend < 0.001). Multiple regression analysis showed that age, sex, and body height were significantly correlated with the aortic circumference at all five measurement sites, while severe atherosclerosis was correlated with the aortic circumference at the root, and descending and abdominal portions. Six contributing factors (age, sex, body height, smoking history, hypertension, and severe atherosclerosis) explained 68.5% of the variance in circumference in the descending portion; age explained 57.5%; sex 8.4%; body height 1%; and severe atherosclerosis 0.8%.Conclusion: The contribution of atherosclerosis to aortic dilation was very weak, representing less than one seventieth of the contribution of age. The aortic circumference, especially in the descending portion, serves as an excellent age-related marker.