A prospective study of gout and cancer
A prospective study of gout and cancer
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DOI：
10.1097/cej.0b013e328313631a
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发表时间：
2009-04-01
影响因子：
2.4
通讯作者：
Ye, Weimin
中科院分区：
文献类型：
--
作者：
Boffetta, Paolo;Nordenvall, Caroline;Ye, Weimin
痛风患者患癌症的风险可能会因为肥胖和大量饮酒而增加，但尿酸具有抗氧化特性，可能会防止癌症发生。我们比较了1965-1995年间在瑞典医院住院的16857名痛风患者的癌症发病率与全国人口的发病率。痛风患者共确诊恶性肿瘤1425例(标化发病率比1.25，95%可信限1.18，1.31)。在痛风患者中，口腔和咽癌、结肠癌、肝癌和胆道癌、胰腺癌、肺癌、皮肤癌(黑色素瘤和非黑色素瘤)、子宫内膜和肾癌以及恶性黑色素瘤的发病率均有所增加。除肺癌外，在整个随访过程中，风险仍然很高。这项研究没有提供尿酸具有保护作用的证据。高尿酸血症可能是致癌过程的早期表现。《欧洲癌症预防杂志》18：127-132(C)2009，Wolters Kluwer Health，竖条，Lippincott Williams&Wilkins。
Gout patients might be at an increased risk of cancer because of obesity and heavy alcohol drinking, but uric acid has antioxidant properties, which may protect against carcinogenesis. We compared the incidence of cancer among 16 857 gout patients admitted to hospitals in Sweden during 1965-1995 with that of the national population. A total of 1425 malignant neoplasms were diagnosed in gout patients (standardized incidence ratio 1.25, 95% confidence limits 1.18,1.31). The incidence of cancers of the oral cavity and pharynx, colon, liver and biliary tract, pancreas, lung, skin (melanoma and nonmelanoma), endometrium and kidney, as well as of malignant melanoma was increased among gout patients. With the exception of lung cancer, the risk remained elevated during the entire follow-up. This study provides no evidence of a protective effect of uric acid. Hyperuricemia may be an early manifestation of the carcinogenic process. European Journal of Cancer Prevention 18:127-132 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.