Dysfunction of resolution receptor triggers cardiomyopathy of obesity and signs of non-resolving inflammation in heart failure.

Dysfunction of resolution receptor triggers cardiomyopathy of obesity and signs of non-resolving inflammation in heart failure.
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DOI:
10.1016/j.mce.2021.111521
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发表时间:
2022-02-15
影响因子:
4.1
通讯作者:
Halade, Ganesh, V
Halade, Ganesh, V
中科院分区:
医学2区
文献类型:
--
作者:
Kain, Vasundhara;Halade, Ganesh, V

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射血分数保留性心力衰竭(HFpEF)是一种新兴的心脏疾病类型,因为假性左心室功能得以保留;因此,寻找靶点和治疗具有挑战性。损伤和病原体相关的分子模式(DAMPs和PAMPs)在心力衰竭的急性和慢性炎症中被广泛研究;然而,生活方式相关的分子模式(LAMPs:饮食,睡眠,运动),特别是在肥胖症中,由于HFpEF患者的大量增加,仍然令人感兴趣。在这篇综述中,我们涵盖了肥胖相关的心肌病,LAMPs和分辨率受体功能障碍的背景下,心力衰竭与保留射血分数。
Heart failure with preserved ejection fraction (HFpEF) has been an emerging type of cardiac disease since the pseudo-left ventricle function is preserved; therefore, challenges in finding the target and treatment. Damage and pathogen-associated molecular patterns (DAMPs and PAMPs) are widely investigated in acute and chronic inflammation in heart failure; however, lifestyle-associated molecular patterns (LAMPs: diet, sleep, exercise), particularly in obesity, remains of interest due to the enormous increase of HFpEF patients. In this review, we covered obesity-related cardiomyopathy, LAMPs, and resolution receptor dysfunction in the context of heart failure with preserved ejection fraction.
DOI: 10.1126/scisignal.aao1818
发表时间: 2018-03-06
期刊: Science signaling
影响因子: 7.3
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