Tobacco Cessation May Improve Lung Cancer Patient Survival.
Tobacco Cessation May Improve Lung Cancer Patient Survival.
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DOI：
10.1097/jto.0000000000000578
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Reid M
中科院分区：
文献类型：
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作者：
Dobson Amato KA;Hyland A;Reed R;Mahoney MC;Marshall J;Giovino G;Bansal-Travers M;Ochs-Balcom HM;Zevon MA;Cummings KM;Nwogu C;Singh AK;Chen H;Warren GW;Reid M
本研究描述了罗斯威尔公园癌症研究所（NCI指定的综合癌症中心）肺癌患者的戒烟模式以及戒烟与生存率的关系。在该机构就诊的肺癌患者进行了标准化烟草评估筛查，过去30天内使用烟草的患者被自动转介到基于电话的戒烟服务。通过电子病历和RPCI肿瘤登记处获得了2010年10月至2012年10月期间转诊至该服务的所有肺癌患者的人口统计学、临床信息和末次联系时自我报告的烟草使用情况。使用描述性统计和考克斯比例风险模型来评估戒烟和其他因素是否与2014年5月之前的肺癌生存率相关。在388名肺癌患者中，有313名被转介到戒烟服务中心。80%的患者（250/313）成功联系并参与了至少一次电话戒烟电话; 40.8%（102/250）的联系人报告在最后一次联系时戒烟。在控制了年龄、吸烟年史、性别、ECOG体能状态、诊断与末次联系之间的时间、肿瘤组织学和临床分期后，与末次联系时继续吸烟相比，戒烟可显著延长生存期（HR=1.79; 95% CI：1.14-2.82），总生存期中位延长9个月。肺癌患者诊断后戒烟可能会增加总生存率。
This study characterizes tobacco cessation patterns and the association of cessation with survival among lung cancer patients at Roswell Park Cancer Institute: an NCI Designated Comprehensive Cancer Center. Lung cancer patients presenting at this institution were screened with a standardized tobacco assessment, and those who had used tobacco within the past 30 days were automatically referred to a telephone-based cessation service. Demographic, clinical information and self-reported tobacco use at last contact were obtained via electronic medical records and the RPCI tumor registry for all lung cancer patients referred to the service between October 2010 and October 2012. Descriptive statistics and Cox proportional hazards models were used to assess whether tobacco cessation and other factors were associated with lung cancer survival through May 2014. Calls were attempted to 313 of 388 lung cancer patients referred to the cessation service. Eighty percent of patients (250/313) were successfully contacted and participated in at least one telephone-based cessation call; 40.8% (102/250) of persons contacted reported having quit at the last contact. After controlling for age, pack year history, sex, ECOG performance status, time between diagnosis and last contact, tumor histology, and clinical stage, a statistically significant increase in survival was associated with quitting compared to continued tobacco use at last contact (HR=1.79; 95% CI: 1.14-2.82) with a median 9 month improvement in overall survival. Tobacco cessation among lung cancer patients after diagnosis may increase overall survival.