Hair cortisol and cognitive performance in working age adults
Hair cortisol and cognitive performance in working age adults
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DOI：
10.1016/j.psyneuen.2016.01.029
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发表时间：
2016-05-01
影响因子：
3.7
通讯作者：
Kliegel, Matthias
中科院分区：
文献类型：
--
作者：
McLennan, Skye N.;Ihle, Andreas;Kliegel, Matthias
据推测，长期暴露于高皮质醇水平会导致认知障碍。然而，以前的研究皮质醇和认知之间的关系产生了混合的结果，最有可能是由于难以实现有效的估计长期皮质醇暴露的基础上唾液或血浆皮质醇评估在一个单一的时间点。此外，关于长期暴露于皮质醇对工作年龄成年人的认知影响的研究很少。在本研究中，头发样本收集246护士（89.8%的女性），年龄在21 - 62（M=42.0，SD=11.2）。在近端3厘米的头发部分的头发皮质醇浓度（HCC）进行了分析，提供了一个估计的综合皮质醇分泌超过3个月的时间之前，头发采样。认知是使用一组15个神经心理学测试来测量的，测量记忆、归纳推理、处理速度、结晶智力和执行功能的主要方面的核心维度。HCC与测量的任何认知能力均无显著相关，无论是在控制潜在调节因素（如年龄、性别、教育、健康、幸福感、工作能力和倦怠）之前还是之后。非线性关系的测试也产生了不显著的结果。因此，尽管这项研究具有很好的动力，但长期皮质醇暴露似乎与这个工作年龄成年人样本的认知表现无关，这表明长期皮质醇暴露与年轻人和中年人的认知相关性可能比以前认为的要小。(C)2016爱思唯尔有限公司版权所有
It has been hypothesized that prolonged exposure to high cortisol levels results in cognitive impairment. However, previous research into the relationship between cortisol and cognition has produced mixed results, most likely due to difficulties achieving valid estimates of long-term cortisol exposure based on salivary or plasma cortisol assessments at a single time point. Furthermore, there has been little research on the cognitive effects of long-term cortisol exposure in working-age adults. In the present study, hair samples were collected from 246 nurses (89.8% female) aged from 21 to 62 (M=42.0, SD=11.2). Hair cortisol concentrations (HCC) in the proximal 3-cm hair segment were analyzed providing an estimate of integrated cortisol secretion over the 3 month-period prior to hair sampling. Cognition was measured using a battery of 15 neuropsychological tests, measuring core dimensions of memory, inductive reasoning, processing speed, crystalized intelligence and major aspects of executive functioning. HCC was not significantly related to any of the cognitive abilities measured, either before or after controlling for potential moderators such as age, sex, education, health, well-being, work ability and burnout. Tests for nonlinear relationships also yielded non-significant results. Thus, despite the study being well powered, long term cortisol exposure did not appear to be related to cognitive performance in this sample of working-age adults, suggesting that long term cortisol exposure may be less relevant to cognition in younger and middle-aged adults than was previously thought. (C) 2016 Elsevier Ltd. All rights reserved.