Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors
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DOI：
10.1038/sj.onc.1207869
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发表时间：
2004-11-04
期刊：
影响因子：
8
通讯作者：
Tsuruo, T
中科院分区：
文献类型：
--
作者：
Kato, Y;Sasagawa, I;Tsuruo, T
聚集蛋白（也称为T1 α/podoplanin）是一种膜唾液酸糖蛋白，其在肿瘤中的功能尚不清楚。我们最近确定Aggrus具有诱导血小板聚集的能力，并且其表达在结直肠肿瘤中频繁上调。因此，Aggrus表达可能与肿瘤诱导的血小板聚集和肿瘤转移有关。在这里，我们显示，通过癌症亲。Ling阵列和实时PCR显示，与周围正常组织相比，睾丸生殖细胞肿瘤中aggrus mRNA表达频繁上调。免疫组化染色显示Aggrus蛋白在11例乳腺癌中有10例（90.9%）表达，而在胚胎性癌中无表达（0/4; 0%）。睾丸腺瘤的特异性标志物尚未报道，而Aggrus是睾丸腺瘤的潜在诊断标志物，可能与睾丸恶性肿瘤相关。
Aggrus ( also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated with tumor-induced platelet aggregation and tumor metastasis. Here we show, by means of cancer pro. ling array and real-time PCR, that aggrus mRNA expression is frequently upregulated in testicular germ cell tumors when compared with the surrounding normal tissue. Immunohistochemical staining revealed that Aggrus protein expression was detected in 10 of 11 seminomas (90.9%), but its expression was not observed in embryonal carcinomas (0/4; 0%). Specific markers for seminomas have not been reported, and Aggrus is a potential diagnostic marker for seminomas and may be associated with malignancies of the testis.