Acellular dermal matrix as an adjunct in treatment of neuropathic pain at the wrist
Acellular dermal matrix as an adjunct in treatment of neuropathic pain at the wrist
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DOI：
10.1097/01.ta.0000224139.74143.f9
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发表时间：
2006-08-01
影响因子：
--
通讯作者：
Adham, Mehdi N.
中科院分区：
文献类型：
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作者：
Peterson, Steven L.;Adham, Mehdi N.
背景：腕部浅表感觉神经的创伤或手术损伤可导致严重的发病率。已经提出了多种治疗方式，包括使用皮瓣覆盖来提供软组织填充和减少触觉刺激。在本报告中，脱细胞真皮基质，（Alloderm）被用作皮瓣覆盖的替代方法，从而避免了对供皮区的需要。方法：5例术后和5例创伤后神经病理性疼痛的腕部患者接受了神经瘤切除和/或神经松解术，然后在皮肤和神经之间插入脱细胞异体真皮基质。患者随访12至25个月，疼痛明显改善。八个以前受雇的患者返回到他们以前的occupations.Conclusions：真皮基质异体移植物可以提供缓冲和/或滑动表面的神经，并代表一个简单的替代皮瓣覆盖在手腕神经性疼痛的治疗。
Background:. Traumatic or surgical injury to superficial sensory nerves at the wrist can lead to significant morbidity. Multiple treatment modalities have been proposed, including the use of flap coverage to provide soft-tissue padding and decrease tactile irritation. In this report, acellular dermal matrix (AlloDerm) was used as an alternative to flap coverage, thereby avoiding the need for a donor site.Methods: Five patients with postsurgical and five patients with posttraumatic neuropathic pain at the wrist underwent neuroma excision and/or neurolysis followed by interposition of acellular dermal matrix allograft between skin and nerve.Results: Patients were followed from 12 to 25 months and demonstrated substantial improvement in pain. Eight previously employed patients returned to their prior occupations.Conclusions: Dermal matrix allograft may provide cushioning and/or a gliding surface for the nerve and represents a simple alternative to flap coverage in the treatment of neuropathic pain at the wrist.