The secreted proteome profile of developing Dictyostelium discoideum cells
The secreted proteome profile of developing Dictyostelium discoideum cells
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DOI：
10.1002/pmic.200900516
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发表时间：
2010-07-01
期刊：
影响因子：
3.4
通讯作者：
Gomer, Richard H.
中科院分区：
文献类型：
--
作者：
Bakthavatsalam, Deenadayalan;Gomer, Richard H.
盘基网眼菌是一种单细胞真核生物，饥饿时会聚集形成多细胞结构。在这份报告中，我们使用基于MS的蛋白质组学方法鉴定了发育中的网柄苔藓细胞所分泌的蛋白质。共鉴定出349个不同的分泌蛋白，表明在网柄藻基因组预测的13600个蛋白质中，至少有2.6%是分泌的基因本体论分析表明，许多分泌蛋白参与了蛋白质和碳水化合物的代谢以及蛋白质的降解
Dictyostelium discoideum is a unicellular eukaryote that, when starved, aggregates to form multicellular structures. In this report, we identified the proteins secreted by developing Dictyostelium cells using MS-based proteomics. A total of 349 different secreted proteins were identified, indicating that at least 2.6% of the 13 600 predicted proteins in the Dictyostelium genome are secreted Gene ontology analysis suggests that many of the secreted proteins are involved in protein and carbohydrate metabolism, and proteolysis