BRANCHING OF REGENERATING RETINAL AXONS AND PREFERENTIAL SELECTION OF APPROPRIATE BRANCHES FOR SPECIFIC NEURONAL CONNECTION IN THE NEWT
BRANCHING OF REGENERATING RETINAL AXONS AND PREFERENTIAL SELECTION OF APPROPRIATE BRANCHES FOR SPECIFIC NEURONAL CONNECTION IN THE NEWT
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DOI：
10.1016/0012-1606(82)90210-x
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发表时间：
1982-01-01
影响因子：
2.7
通讯作者：
IBATA, Y
中科院分区：
文献类型：
--
作者：
FUJISAWA, H;TANI, N;IBATA, Y
成年蝾螈C视神经切断后第4、6和10周，通过用辣根过氧化物酶（HRP）标记选定的视网膜轴突，在顶盖内检测来自不同视网膜象限的单个再生视网膜轴突的精确轨迹和分支模式。红腹菌在再生的早期阶段，每个再生的视网膜轴突在顶盖内以随机的方向萌发出几个分支。随着再生的进行，只有指向正常神经支配部位的分支被保持，而朝向顶盖异位部分的萌芽被缩回或变得萎缩。幸存下来的树枝又长出了几根新的树枝。在整个再生过程中，新枝的萌发和老枝的消失是同时发生的。在再生的第10周，大多数再生的视网膜轴突只在正常神经支配的部位内的远端部分具有分支。再生视网膜轴突的视网膜定位中枢连接可以通过逐步选择广泛的轴突分支来重建。
Exact trajectory and pattern of branching of individual regenerating retinal axons derived from different retinal quadrants was detected within the tectum by labeling selected retinal axons with horseradish peroxidase (HRP) at the 4th, 6th and 10th wk after transection of the optic nerve in adult newt C. pyrrhogaster. In the early phase of regeneration, each regenerating retinal axon sprouted several branches, in random directions within the tectum. As the regeneration proceeded, only branches directed toward the site of normal innervation were maintained, while the sproutings toward the ectopic part of the tectum were retracted or became atrophic. The surviving branches then sprouted several new branches. Sprouting of new branches and the disappearance of old branches occurred simultaneously throughout the process of regeneration. At the 10th wk of regeneration, most regenerating retinal axons possessed branches only at the distal part within the site of normal innervation. The retinotopic central connection of regenerating retinal axons may be reestablished by means of a stepwise selection of widespread axonal branches.