Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.
Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.
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DOI：
10.1007/s12671-022-01857-z
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发表时间：
2022-05
期刊：
影响因子：
3.6
通讯作者：
Fredrickson, Barbara L
中科院分区：
文献类型：
--
作者：
West, Taylor N;Zhou, Jieni;Brantley, Mary M;Kim, Sumi L;Brantley, Jeffrey;Salzberg, Sharon;Cole, Steve W;Fredrickson, Barbara L
在低社会经济地位（SES）家庭中长大的人在成年后患身体疾病的风险增加。免疫系统中基因表达谱的转变是一种被认为是导致疾病易感性升高的生物学机制，其中经常研究的谱是对逆境的保守转录反应（CTRA），其特征在于促炎基因的表达增加和抗病毒和抗体相关基因的表达减少。本研究调查了处于风险中的中年成人（N = 88）的样本，与随机学习正念冥想（MM）的人相比，那些随机学习慈爱冥想（LKM）的人在6周的研讨会上是否会显示CTRA基因表达的减少。我们每天评估情绪，并假设积极的情绪来解释LKM对基因表达的预期影响。结果显示，干预前后存在显著的组间差异，但与假设的方向相反：随机分配到MM组的参与者CTRA基因表达显著下降，而LKM组的参与者CTRA基因表达显著增加。在6周的时间里，两组患者的积极情绪都有所增加（B= 0.007，p <0.001），而消极情绪则有所减少（B=-0.005，p <0.001）。因此，积极的情绪并没有被追求作为观察到的群体效应的候选调解人。这项研究是第一个研究童年低SES的生物影响是否可以通过冥想干预在中年逆转。结果表明，正念冥想可能是改善这一高危人群健康状况的可行选择。试用注册：ClinicalTrials.gov NCT 02400593。
People raised in low socio-economic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently-investigated profile being the conserved transcriptional response to adversity (CTRA), characterized by increased expression of proinflammatory genes and decreased expression of antiviral and antibody-related genes The present study investigated, in a sample of at-risk midlife adults (N = 88), whether those randomized to learn loving-kindness meditation (LKM) in a 6-week workshop, would show a reduction in CTRA gene expression, compared to those randomized to learn mindfulness meditation (MM). We assessed emotions daily and hypothesized positive emotions to account for the expected effect of LKM on gene expression. Results showed significant group differences from pre- to post-intervention, yet in the opposite direction as hypothesized: Participants randomized to the MM group showed significant declines in CTRA gene expression, whereas those in the LKM group showed significant increases in CTRA gene expression. Both groups showed increases over the 6 weeks in daily reports of positive emotions, b=.007, p <.001 alongside decreases in negative emotions b=−.005, p <.001. Thus, positive emotions were not pursued as a candidate mediator of observed group effects This study is the first to examine whether the biological impact of childhood low-SES can be reversed in mid-life through meditation interventions. Results suggest mindfulness meditation may be a viable option for improving health outcomes in this at-risk population. Trial Registration: ClinicalTrials.gov NCT02400593.