Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.
Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.
复制标题
cosalane 和相关化合物抑制 RANTES/CCR1 介导的趋化作用。
DOI：
10.1016/s0960-894x(00)00601-6
复制
发表时间：
2001
影响因子：
2.7
通讯作者：
Cushman,M
中科院分区：
文献类型：
--
作者：
Howard,OM;Dong,HF;Oppenheim,JJ;Insaf,S;Santhosh,KC;Paul,G;Cushman,M
抗 HIV 药物 cosalane 及其几种类似物抑制 RANTES 诱导的人类单核细胞迁移，但它们不抑制 MIP1α 或 MIP1β 诱导的迁移。 RANTES 诱导的单受体 CCR1-HEK 转染子的迁移也被 cosalanes 抑制。 RANTES 活性氨基的乙酰化消除了 cosalane 的抑制活性。数据表明，cosalane 及其结构类似物可能通过与 RANTES 结合来干扰 RANTES/CCR1 相互作用。
The anti-HIV agent cosalane and several of its analogues inhibited RANTES-induced migration of human monocytes, but they did not inhibit migration induced by MIP1α or MIP1β. RANTES-induced migration of single receptor CCR1-HEK transfectants was also inhibited by the cosalanes. Acetylation of the reactive amino groups of RANTES abrogated the inhibitory activity of cosalane. The data suggest that cosalane and its structural analogues may interfere with the RANTES/CCR1 interaction by binding to RANTES.