Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease.
Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease.
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在没有缺血性心脏病的2型糖尿病患者中存在左心室质量指数增加。
DOI：
10.1038/s41598-018-19229-w
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发表时间：
2018-01-17
影响因子：
4.6
通讯作者：
Lalic NM
中科院分区：
文献类型：
--
作者：
Seferovic JP;Tesic M;Seferovic PM;Lalic K;Jotic A;Biering-Sørensen T;Giga V;Stankovic S;Milic N;Lukic L;Milicic T;Macesic M;Gajovic JS;Lalic NM
左心室质量指数（LVMI）升高已被描述为高血压（HTN），但其与2型糖尿病（T2DM）的关系尚不清楚。由于这些情况经常共存，我们研究了T2DM、HTN和两者与超声心动图参数的关系，并假设两者的患者LVMI最高，其次是只有T2DM或HTN的患者。研究人群包括101例T2DM患者，62例合并HTN且无T2DM患者，76例合并T2DM并HTN的患者，排除缺血性心脏病。进行了人口统计学和临床资料、生化测量、应激超声心动图、经胸二维多普勒和组织多普勒超声心动图检查。采用多变量logistic回归来确定与T2DM的独立关联。采用线性回归模型和Pearson相关评价LVMI与其他参数的相关性。T2DM患者LVMI（84.9±20.3 g/m2）明显高于T2DM合并HTN患者（77.9±16 g/m2）和HTN患者（69.8±12.4 g/m2）。在多因素logistic回归分析中，T2DM与LVMI相关（OR 1.033, 95%CI 1.003-1.065, p = 0.029）。LVMI与空腹血糖（p < 0.001）和HbA1c （p = 0.0003）呈正相关。LVMI升高可能是T2DM患者心肌结构改变的潜在症状前标志物。
Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients with both had highest LVMI, followed by patients with only T2DM or HTN. Study population included 101 T2DM patients, 62 patients with HTN and no T2DM, and 76 patients with T2DM and HTN, excluded for ischemic heart disease. Demographic and clinical data, biochemical measurements, stress echocardiography, transthoracic 2D Doppler and tissue Doppler echocardiography were performed. Multivariable logistic regression was used to determine the independent association with T2DM. Linear regression models and Pearson’s correlation were used to assess the correlations between LVMI and other parameters. Patients with only T2DM had significantly greater LVMI (84.9 ± 20.3 g/m2) compared to patients with T2DM and HTN (77.9 ± 16 g/m2) and only HTN (69.8 ± 12.4 g/m2). In multivariate logistic regression analysis, T2DM was associated with LVMI (OR 1.033, 95%CI 1.003–1.065, p = 0.029). A positive correlation of LVMI was found with fasting glucose (p < 0.001) and HbA1c (p = 0.0003). Increased LVMI could be a potential, pre-symptomatic marker of myocardial structural change in T2DM.
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影响因子：
9.3
作者：
Ichikawa R;Daimon M;Miyazaki T;Kawata T;Miyazaki S;Maruyama M;Chiang SJ;Suzuki H;Ito C;Sato F;Watada H;Daida H
通讯作者：
Daida H
影响因子：
37.8
作者：
Lieb W;Xanthakis V;Sullivan LM;Aragam J;Pencina MJ;Larson MG;Benjamin EJ;Vasan RS
通讯作者：
Vasan RS
影响因子：
105.7
作者：
Huxley, R;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
影响因子：
7.7
作者：
Levelt E;Mahmod M;Piechnik SK;Ariga R;Francis JM;Rodgers CT;Clarke WT;Sabharwal N;Schneider JE;Karamitsos TD;Clarke K;Rider OJ;Neubauer S
通讯作者：
Neubauer S