EFFECT ON PARKINSONIAN SIGNS AND SYMPTOMS OF BILATERAL SUBTHALAMIC NUCLEUS STIMULATION
EFFECT ON PARKINSONIAN SIGNS AND SYMPTOMS OF BILATERAL SUBTHALAMIC NUCLEUS STIMULATION
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DOI：
10.1016/s0140-6736(95)90062-4
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发表时间：
1995-01-14
期刊：
影响因子：
168.9
通讯作者：
BENABID, AL
中科院分区：
文献类型：
--
作者：
LIMOUSIN, P;POLLAK, P;BENABID, AL
在患帕金森病的猴子中，丘脑底核的损伤和电刺激减少了所有主要的运动障碍。在三名患有失能性运动不能僵硬帕金森病和严重运动波动的患者中评估了丘脑底核电刺激的效果。在两侧的丘脑底核中植入了连接到脉冲发生器的四极电极，采用统一的帕金森病评定量表和定时运动试验对患者进行评估。术后3个月，日常生活活动评分改善58-88%，运动评分改善42- 84%。这种改善在第一位接受手术的患者中维持了长达8个月。1例患者术后2周出现意识模糊，另1例患者出现与丘脑梗死相关的神经心理学损害，3个月后改善。1例患者刺激可诱发冲击症，减少刺激可使其停止。这是首次在人类中证明丘脑底核在帕金森病的病理生理学中所起的作用。
In monkeys rendered parkinsonian, lesions and electrical stimulation of the subthalamic nucleus reduce all major motor disturbances, The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations.Quadripolar electrodes connected to a pulse generator were implanted in the subthalamic nuclei on both sides, Patients were evaluated with the unified Parkinson's disease rating scale and timed motor tests. 3 months after surgery, activities of daily living scores had improved by 58-88% and motor scores by 42-84%. This improvement was maintained for up to 8 months in the first patient operated upon. One patient was confused for 2 weeks after surgery, and another developed neuropsychological impairment related to a thalamic infarction which improved over 3 months, In one patient, stimulation could induce ballism that was stopped by reduction of stimulation.This is the first demonstration in human beings of the part played by the subthalamic nuclei in the pathophysiology of Parkinson's disease.