The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study.
The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study.
复制标题
认知和大脑储备在中晚年记忆衰退和萎缩率中的作用：SMART-MR 研究。
DOI：
10.1016/j.cortex.2021.11.022
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
UCC-SMART-StudyGroup
中科院分区：
文献类型：
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作者：
Vonk,JetMJ;Ghaznawi,Rashid;Zwartbol,MaartenHT;Stern,Yaakov;Geerlings,MirjamI;UCC-SMART-StudyGroup
研究认知和大脑储备与中年和晚年记忆力下降轨迹的关联，以及记忆力下降与萎缩的关系是否与reserve.MethodsParticipants的功能不同，989荷兰中年至老年人从SMART-MR前瞻性队列，随访至12年，最多3个测量记忆和脑MRI。受教育程度和荷兰国家成人阅读测试（DART）被用作认知储备的代表，颅内体积（ICV）和基线脑实质分数（BPF）被用作脑储备的代表。单变量生长曲线模型分析了储备与记忆衰退的关系，多组双变量生长曲线模型测试了纵向脑记忆关系作为储备的函数。模型还分层的中年和late-life.ResultsHigher DART，教育，和BPF相关的记忆衰退的速度较慢，特别是在晚年，但ICV不是。正协方差表明，一个人谁经历萎缩也经历记忆力下降这种关系并没有不同的认知或大脑储备，但不存在于中年。记忆力下降速度比大脑容量下降速度慢，但低DART、教育和BPF组的速度更为相似。讨论较高的认知能力（DART、教育）和大脑储备（BPF）在纵向记忆变化中发挥保护作用。ICV是大脑储备的一个不适当的代理，在基线或随着时间的推移，未能显示与记忆表现的任何关联。解构储备能力与纵向认知和大脑结果的关系，可以确定具有干预潜力的重点领域。
ObjectiveInvestigate associations of cognitive and brain reserve with trajectories of memory decline in mid-life and late-life, and whether the relationship of memory decline with atrophy differs as a function of reserve.MethodsParticipants were 989 Dutch middle-aged to older adults from the SMART-MR prospective cohort, followed up to 12 years with up to 3 measurements of memory and brain MRI. Education and Dutch National Adult Reading Test (DART) were used as proxies of cognitive reserve, and intracranial volume (ICV) and baseline brain parenchymal fraction (BPF) for brain reserve. Univariate growth curve models analyzed associations of reserve with memory decline, and multiple-group bivariate growth curve models tested the longitudinal brain–memory relationship as a function of reserve. Models were additionally stratified by mid-life and late-life.ResultsHigher DART, education, and BPF were related to a slower rate of memory decline, particularly in late-life, but ICV was not. A positive covariance indicated that an individual who undergoes atrophy also undergoes memory decline—this relationship did not differ across cognitive or brain reserve, but was not present in mid-life. Memory declined slower than brain volume, yet rates were more similar in the low DART, education, and BPF groups.DiscussionHigher cognitive (DART, education) and brain reserve (BPF) work protectively in longitudinal memory change. ICV is an inappropriate proxy of brain reserve, failing to show any association with memory performance at baseline or over time. Deconstructing relationships of reserve capacities with longitudinal cognitive and brain outcomes may identify focus areas with potential for intervention.