Hydration and percutaneous absorption II: Influence of hydration on water and alkanol permeation through Swiss mouse skin; comparison with hairless mouse.
Hydration and percutaneous absorption II: Influence of hydration on water and alkanol permeation through Swiss mouse skin; comparison with hairless mouse.
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水合作用和经皮吸收II：水合作用对瑞士小鼠皮肤水和烷醇渗透的影响；
DOI：
10.1002/jps.2600701108
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发表时间：
1981
影响因子：
3.8
通讯作者：
Michael Barrett
中科院分区：
文献类型：
--
作者：
C. R. Behl;Michael Barrett
用生物膜进行的体外渗透研究通常涉及组织的长时间水性浸渍。本研究探讨了水合作用对瑞士小鼠皮肤屏障完整性的可能影响;使用水、甲醇、乙醇和丁醇作为渗透剂，以及先前开发的涉及每片皮肤上多次连续渗透运行的程序。水的渗透速率几乎线性增加到30小时的水合作用，然后趋于平稳。甲醇和乙醇的运输速率渐近增加，然后在约15 hr. These结果与早期的研究结果对比无毛小鼠皮肤这三种化合物的渗透性不受水浸泡。丁醇的渗透率也增加，在第一个15小时的水合作用，但在接下来的25小时逐渐下降。这一结果再次与无毛小鼠的丁醇渗透性在10小时内翻了一番，然后趋于稳定。在水合配置文件中的物种差异似乎与非常不同的皮，在瑞士小鼠，可能表明更大的参与transfollicular途径。
In vitro permeation studies with biological membranes often involve long, aqueous maceration of the tissue. The present investigation examined the possible effects of hydration on barrier integrity of Swiss mouse skin; using water, methanol, ethanol, and butanol as permeants and a previously developed procedure involving multiple, sequential permeation runs on each piece of skin. The permeation rate of water increased almost linearly up to 30 hr of hydration and then tended to level off. Transport rates of methanol and ethanol increased asymptotically and then plateaued at approximately 15 hr. These results contrast with earlier findings on hairless mouse skin where the permeabilities of these three compounds were unaffected by aqueous immersion. The permeation rate of butanol also increased during the first 15 hr of hydration but gradually declined over the next 25 hr. This result again contrasts with the hairless mouse species in which butanol permeability doubled in 10 hr and then plateaued. The species differences in the hydration profiles appear related to the vastly dissimilar pellages and, in the Swiss mouse, may indicate greater involvement of the transfollicular pathway.