SPECIFIC SENSITIVITY OF PATIENTS WITH PANIC ATTACKS TO CARBON-DIOXIDE INHALATION
SPECIFIC SENSITIVITY OF PATIENTS WITH PANIC ATTACKS TO CARBON-DIOXIDE INHALATION
复制标题
DOI：
10.1016/0165-1781(90)90121-k
复制
发表时间：
1990-02-01
影响因子：
11.3
通讯作者：
LOUSBERG, H
中科院分区：
文献类型：
--
作者：
GRIEZ, E;DELOOF, C;LOUSBERG, H
36名焦虑症患者和14名健康对照者吸入了35%的二氧化碳氧气。18名患者被诊断为惊恐障碍（PD）和18名强迫症（OCD）。作为CO2的安慰剂对照，以双盲设计给予压缩空气。在吸入之前和之后，立即评估焦虑水平和DSM-III-R恐慌症状。CO2-引起高水平的主观焦虑的PD组。强迫症患者几乎不受吸入的影响，与健康对照组没有区别。这些结果表明，二氧化碳挑战应被视为一个特定的探针与惊恐焦虑的主题。据推测，二氧化碳可能会触发一些尚未确定的机制，可能与通气控制有关，这将恐慌与其他类型的病理性焦虑区分开来。
One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately before and after the inhalation, levels of anxiety and DSM-III-R symptoms of panic were assessed. CO2-elicited high levels of subjective anxiety in the PD group. Patients with OCD were hardly affected by the inhalation, and did not differ from healthy controls. These results suggest that CO2 challenge should be considered as a specific probe for subjects with panic-anxiety. It is speculated that CO2 may trigger some as yet undefined mechanism, possibly linked to ventilation control, which demarcate panic from other types of pathological anxiety.