Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese
Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese
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DOI：
10.1093/carcin/bgm074
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发表时间：
2007-09-01
期刊：
影响因子：
4.7
通讯作者：
Hishida, Akira
中科院分区：
文献类型：
--
作者：
Sugimoto, Mitsushige;Furuta, Takahisa;Hishida, Akira
背景和目标：血管紧张素原（AGT）、血管紧张素I和血管紧张素II（Angiotensin I，Angiotensin II）等肾素-血管紧张素（renin-angiotensin，RA）系统参与细胞增殖、血管生成和炎症的调节。AGT-20 A/C多态性与血浆AGT和血管紧张素II水平相关。本研究的目的是阐明AGT-20 A/C多态性与日本人胃癌和消化性溃疡易感性的关系。研究方法：我们评估了AGT-20 A/C多态性在幽门螺杆菌阳性的胃癌患者（n = 135），胃溃疡（n = 148）和十二指肠溃疡（n = 113）和对照组（n = 292）组成的幽门螺杆菌阳性胃炎（n = 160）和幽门螺杆菌阴性的受试者（n = 132）。结果如下：AGT-20基因A/C和C/C基因型与A/A基因型胃癌风险的年龄和性别校正比值比（OR）分别为1.695（95%CI：1.035-2.777）和2.259（95%CI：0.351-14.533）。AGT-20 C等位基因增加胃癌的危险性（OR：1.685，95% CI：1.037-2.736），尤其是肠型胃癌（OR：1.792，95% CI：1.040-3.089）。然而，AGT-20多态性与消化性溃疡的易感性之间没有关联。结论：AGT-20 C等位基因的携带与日本人幽门螺杆菌相关胃癌发生的风险增加相关，表明RA系统在胃癌发病机制中起重要作用。
Backgrounds and aims: The renin-angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell proliferation, angiogenesis and inflammation. AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese. Methods: We assessed the AGT-20 A/C polymorphism in Helicobacter pylori-positive patients with gastric cancer (n = 135), gastric ulcer (n = 148) and duodenal ulcer (n = 113) and controls (n = 292) consisting of H.pylori-positive gastritis alone (n = 160) and H.pylori-negative subjects (n = 132). Results: The age- and sex-adjusted odds ratios (ORs) of AGT-20 A/C and C/C genotypes relative to A/A genotype for gastric cancer risk were 1.695 [95% confidence interval (CI): 1.035-2.777] and 2.259 (95% CI: 0.351-14.533), respectively. The AGT-20 C allele increased the gastric cancer risk (OR: 1.685, 95% CI: 1.037-2.736), especially the intestinal type of gastric cancer (OR: 1.792, 95% CI: 1.040-3.089). However, there was no association between the AGT-20 polymorphism and susceptibility to peptic ulcer. Conclusions: The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer.