Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis
Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis
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共同暴露于环境浓度的顺式联苯菊酯和氧化石墨烯：非洲爪蟾变态发育过程中对神经系统的不利影响
DOI：
10.1016/j.jhazmat.2019.120995
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发表时间：
2020-01-05
影响因子：
13.6
通讯作者：
Zhou, Bingsheng
中科院分区：
文献类型：
--
作者：
Li, Meng;Zhu, Jiaping;Zhou, Bingsheng
尽管纳米颗粒和杀虫剂的联合生物效应引起了极大的关注，但目前对相应生态风险的理解仍然有限。非洲爪蟾Xenopus laevis（X. laevis）蝌蚪暴露于单独或与氧化石墨烯（GO）组合的各种浓度的典型拟除虫菊酯（顺式-联苯菊酯;顺式-BF）21天。GO的存在导致增加的生物浓度的顺式-BF和更高的1 S-对映体馏分。暴露于顺式-BF和GO引起进一步减少前变质的发展速度和激活多巴胺能，去甲肾上腺素能，和多巴胺能神经递质系统。在共同暴露组中观察到蝌蚪活动减少和基因组DNA胞嘧啶核苷酸甲基化水平（5 hmC）。这些结果表明，GO增强生物富集的顺式BF，并促进其1 R-对映异构体转化为1 S形式，这导致神经递质系统的破坏以及在变态发展的干扰。
Despite the great concerns associated with the combined biological effects of nanoparticles and insecticides, the current understanding of the corresponding ecological risks remains limited. Xenopus laevis (X. laevis) tadpoles were exposed to various concentrations of typical pyrethroid (cis-bifenthrin; cis-BF), either alone or in combination with graphene oxide (GO), for 21 days. The presence of GO resulted in increased bioconcentration of cis-BF and a higher 1S-enantiomer fraction. Exposure to cis-BF and GO caused further reduction in pre-metamorphic developmental rates and activated dopaminergic, noradrenergic, and serotonergic neurotransmitter systems. Reduced tadpole activity and levels of genomic DNA methylation at cytosine nucleotides (5hmC) were observed in the coexposure groups. These results indicate that GO enhance the bioconcentration of cis-BF and promote the conversion of its 1R-enantiomer to the 1S form, which lead to disruption of neurotransmitter systems as well as interference in metamorphic development.