Cortical area size dictates performance at modality-specific behaviors
Cortical area size dictates performance at modality-specific behaviors
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DOI：
10.1073/pnas.0611723104
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发表时间：
2007-03-06
影响因子：
11.1
通讯作者：
O'Leary, Dennis D. M.
中科院分区：
文献类型：
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作者：
Leingartner, Axel;Thuret, Sandrine;O'Leary, Dennis D. M.
哺乳动物的新皮层被组织成独特的区域，这些区域提供诸如感官知觉和特定于模态的行为等功能。初级皮质区的大小在不同物种之间存在差异，在同一物种内也存在差异，这就提出了一个问题，即区域大小是否决定了行为表现。我们发现，成年小鼠的基因工程过表达的转录因子EMX2在胚胎皮质祖细胞，导致在体感和运动区域的大小减少，表现出显着的缺陷，在触觉和运动行为。甚至通过降低皮层EMX2水平来增加感觉运动区域的大小也会导致感觉运动行为的减少。保留异位Emx2转基因表达的遗传杂交皮层下，但恢复皮质Emx2表达的野生型水平也恢复皮质区野生型的大小，并在平行恢复触觉和运动行为的野生型性能。这些研究结果表明，面积大小可以决定性能在特定的行为和建议，该地区有一个最佳的大小，其神经系统的参数的影响，最大的行为表现。这项研究强调了在胚胎发育过程中建立适当水平的调节蛋白的重要性，这些调节蛋白决定了面积大小，从而影响了以后的生活行为。
The mammalian neocortex is organized into unique areas that serve functions such as sensory perception and modality-specific behaviors. The sizes of primary cortical areas vary across species, and also within a species, raising the question of whether area size dictates behavioral performance. We show that adult mice genetically engineered to overexpress the transcription factor EMX2 in embryonic cortical progenitor cells, resulting in reductions in sizes of somatosensory and motor areas, exhibit significant deficiencies at tactile and motor behaviors. Even increasing the size of sensorimotor areas by decreasing cortical EMX2 levels can lead to diminished sensorimotor behaviors. Genetic crosses that retain ectopic Emx2 transgene expression subcortically but restore cortical Emx2 expression to wild-type levels also restore cortical areas to wild-type sizes and in parallel restore tactile and motor behaviors to wild-type performance. These findings show that area size can dictate performance at modality-specific behaviors and suggest that areas have an optimal size, influenced by parameters of its neural system, for maximum behavioral performance. This study underscores the importance of establishing during embryonic development appropriate levels of regulatory proteins that determine area sizes, thereby influencing behavior later in life.