Behavioral and cellular level changes in the aging somatosensory system.
Behavioral and cellular level changes in the aging somatosensory system.
复制标题
衰老体感系统的行为和细胞水平变化。
DOI：
10.1111/j.1749-6632.2009.04011.x
复制
发表时间：
2009
影响因子：
5.2
通讯作者：
Albers,KathrynM
中科院分区：
文献类型：
--
作者：
Wang,Shuying;Albers,KathrynM
A study of the peripheral sensory system of young and aged Blk6 mice obtained from the National Institutes on Aging mouse colony is described. Behavioral assays showed male and female aged mice had decreased sensitivity to thermal stimuli. The receptor for the growth factor artemin (Artn), GFRα3, and the ion channel TRPV1, which is expressed by 95–99% of GFRα3‐positive primary sensory neurons, was also decreased. Calcium imaging of isolated dorsal root ganglia neurons grown with nerve growth factor was used to test thein vitroeffects of Artn on TRPV1 activation by capsaicin in young and old neurons. Artn potentiated initial TRPV1 responses to capsaicin in young and old neurons, but the percent of capsaicin responders following repeated exposure to capsaicin increased only in young neurons. The lack of change in aged neurons suggests that differences in TRPV1 responses occur with aging in the somatosensory system.
