Cancer Gene Therapy
Cancer Gene Therapy
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DOI：
10.1177/153303460500400402
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发表时间：
2005-02
影响因子：
2.8
通讯作者：
Masato Yamamoto;D. Curiel
中科院分区：
文献类型：
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作者：
Masato Yamamoto;D. Curiel
某些类型的癌症患者在诊断时往往无法切除，其预后仍然令人沮丧。在这些领域，需要开发一种新的治疗方式，基因治疗是一种很有前途的策略。到目前为止，许多基于这些原则的癌症基因治疗临床试验已经进行，并显示出这种方式的安全性，但还没有达到最初治愈癌症的预期。在这篇综述中，我们主要以胃肠道癌症为例，以问题为导向，讨论癌症基因治疗的研究现状。为了克服癌症基因治疗全面实现的障碍，许多研究者进行了大量的研究。各种癌症选择性和非选择性基因，以及裂解病毒本身已被用于基因治疗。在基因传递方法的背景下，不同类型的病毒和非病毒策略已被使用。此外，替代测定法，如可溶性标记物和成像，已被开发用于更安全、信息更丰富的临床试验。迄今为止，许多实验和临床试验已经找出了实现有效的癌症基因治疗方式的当前障碍。克服这些障碍的不懈努力和不断向这一领域注入新概念应该会带来技术突破和患者的治愈。
The prognosis of patients with some kinds of cancers whose patients are often found unresectable upon diagnosis is still dismal. In these fields, development of a new therapeutic modality is needed and gene therapy represents one promising strategy. So far, numerous cancer gene therapy clinical trials based on these principles have been carried out and have shown the safety of such modalities, but have fallen short of the initial expectations to cure cancers. In this review, we would like to make a problem-oriented discussion of current status of cancer gene therapy research by using mainly gastrointestinal cancers as an example. In order to overcome obstacles for full realization of cancer gene therapy, numerous researches have been conducted by many researchers. Various cancer-selective and non-selective genes, as well as lytic viruses themselves have been employed for gene therapy. In the context of gene delivery method, different kinds of viral and non-viral strategies have been utilized. In addition, surrogate assays, such as soluble markers and imaging, have been developed for safer and more informative clinical trials. Many experiments and clinical trials to date have figured out current obstacles for the realization of an effective cancer gene therapy modality. Tireless efforts to overcome such hurdles and continuous infusion of novel concepts into this field should lead to break through technologies and the cure of the patients.