Relationships of Alcohol Consumption with Coronary Risk Factors and Macro- and Micro-Nutrient Intake in Japanese People: The INTERLIPID Study
Relationships of Alcohol Consumption with Coronary Risk Factors and Macro- and Micro-Nutrient Intake in Japanese People: The INTERLIPID Study
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DOI：
10.3177/jnsv.67.28
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发表时间：
2021-01-01
影响因子：
1.6
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
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作者：
Matsumoto-Yamauchi, Hiromi;Kondo, Keiko;Ueshima, Hirotsugu
几项研究已经报道了饮酒和冠心病风险之间的J型关系。然而，这种关系的机制仍不清楚。这项研究旨在评估饮酒与已确定的冠心病危险因素以及日本人的宏观/微观营养素摄入量之间的关系。参加INTERLIPID研究的有1090名日本男性和女性，年龄在40-59岁之间，不包括曾经饮酒的人。根据两个7-d酒精记录，参与者被分为不饮酒者(0g/wk)和轻度饮酒者(=300g/wk)。通过四次深入的24小时饮食回顾评估了详细的宏观/微观营养素摄入量，并根据不包括酒精的总能量摄入量进行了调整。我们分析了CHD危险因素和营养摄入量与饮酒的关系。高饮酒者血清高密度脂蛋白胆固醇和血压较高，低密度脂蛋白胆固醇较低。观察到当前吸烟者的比例、吸烟数量和高血压患病率与饮酒量呈J型关系；这些危险因素在饮酒者中最低。高饮酒者碳水化合物和总纤维摄入量较低，蛋白质和膳食胆固醇摄入量较高。这些关联对于男性和女性来说是相似的。饮酒与营养素摄入量以及已确定的冠心病危险因素有关。不饮酒的人在一些冠心病风险因素上比少量饮酒的人更高。这些发现可能会影响饮酒与冠心病风险之间的J型关系。
Several studies have reported a J-shaped relationship between alcohol consumption and coronary heart disease (CHD) risk. However, the mechanisms of this relationship remain unclear. This study aimed to evaluate the relationships of alcohol consumption with established CHD risk factors and with macro-/micro-nutrient intake among Japanese people. Participants were 1,090 Japanese men and women aged 40-59 y enrolled in the INTERLIPID study, excluding former drinkers. Based on two 7-d alcohol records, participants were classified as non-drinkers (0 g/wk), light-drinkers (= 300 g/wk). Detailed macro-/micro-nutrient intake was evaluated using four in-depth 24-h dietary recalls and adjusted for total energy intake excluding alcohol. We analyzed the associations of CHD risk factors and nutrient intake with alcohol consumption. Serum high-density lipoprotein cholesterol and blood pressure were higher and low-density lipoprotein cholesterol was lower among those with higher alcohol consumption. J-shaped relationships with alcohol consumption were observed for the proportion of current smokers, number of cigarettes smoked, and prevalence of hypertension; these risk factors were lowest among light-drinkers. Carbohydrate and total fiber intakes were lower and protein and dietary cholesterol intakes were higher among those with higher alcohol consumption. These associations were similar for men and women. Alcohol consumption was related to nutrient intake as well as established CHD risk factors. Non-drinkers were higher on some CHD risk factors than were light-drinkers. These findings may influence the J-shaped relationship between alcohol consumption and CHD risk.