The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development
The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development
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DOI：
10.1007/978-3-030-34436-8_3
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Thor, Stefan
中科院分区：
文献类型：
--
作者：
Bahrampour, Shahrzad;Thor, Stefan
在中枢神经系统（CNS）发育过程中，发生了一系列复杂的事件，从神经祖细胞的建立开始，随后是它们的不对称分裂和谱系的形成以及神经元和胶质细胞的分化。对果蝇胚胎中枢神经系统的研究表明，Notch信号转导通路在这些事件中至少起着五种不同的作用。在此，我们回顾了Notch信号传导的许多方面，并讨论了确保上下文依赖性和隔室依赖性信号传导的机制。最后，我们讨论了一些悬而未决的问题Notch信号在这个系统中，这可能有影响Notch信号在许多物种。
During central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have revealed that the Notch signal transduction pathway plays at least five different and distinct roles during these events. Herein, we review these many faces of Notch signalling and discuss the mechanisms that ensure context-dependent and compartment--dependent signalling. We conclude by discussing some outstanding issues regarding Notch signalling in this system, which likely have bearing on Notch signalling in many species.