Spatial Relationships of Visuomotor Transformations in the Superior Colliculus Map
Spatial Relationships of Visuomotor Transformations in the Superior Colliculus Map
复制标题
DOI：
10.1152/jn.90688.2008
复制
发表时间：
2008-11-01
影响因子：
2.5
通讯作者：
Munoz, Douglas P.
中科院分区：
文献类型：
--
作者：
Marino, Robert A.;Rodgers, C. Kip;Munoz, Douglas P.
Marino RA, Rodgers CK, Levy R, Munoz DP。上丘图中视觉运动转换的空间关系。中国生物医学工程学报（英文版），2009,31(4):563 - 567。首次发表于2008年8月27日；doi: 10.1152 / jn.90688.2008。与其他运动系统相比，眼球运动系统已被很好地理解；然而，我们还不知道感觉到运动转换的空间细节。本研究通过量化上丘（SC）中视觉和运动反应之间的空间关系来解决这个问题，上丘是一个中脑结构，参与将视觉信息转化为跳跃性运动指令信号。我们收集了两只猴子的150个视觉运动（VM）和28个运动(M)神经元的细胞外单单元记录，这些猴子被训练去执行一个非预测的视觉引导扫视任务，到达110个可能的目标位置。94%（141/150）的VM神经元运动相关放电大于视觉相关放电。在整个VM神经元群中，视觉和运动反应峰值的平均位置在空间上是一致的。视觉反应场（RFs）明显小于且通常包含在运动RFs中。将RFs转换为SC坐标系显著减少了峰值视觉和运动位置之间的任何不一致。RF尺寸随视觉空间偏心率的增加而增加，但在吻侧极1mm以上的SC地图上保持不变。RF形状在SC地图坐标上的对称性显著高于视觉空间坐标。这些结果表明，VM神经元在视野中指定目标刺激的相同位置作为即将到来的扫视的预期位置，与下游结构的偏差最小。将视野坐标空间转换为SC图的计算结果导致视觉-感觉到眼动-运动转换过程中对齐和空间对称性增加。
Marino RA, Rodgers CK, Levy R, Munoz DP. Spatial relationships of visuomotor transformations in the superior colliculus map. J Neurophysiol 100: 2564-2576, 2008. First published August 27, 2008; doi:10.1152/jn.90688.2008. The oculomotor system is well understood compared with other motor systems; however, we do not yet know the spatial details of sensory to motor transformations. This study addresses this issue by quantifying the spatial relationships between visual and motor responses in the superior colliculus (SC), a midbrain structure involved in the transformation of visual information into saccadic motor command signals. We collected extracellular single-unit recordings from 150 visual-motor (VM) and 28 motor (M) neurons in two monkeys trained to perform a nonpredictive visually guided saccade task to 110 possible target locations. Motor related discharge was greater than visual related discharge in 94% (141/150) of the VM neurons. Across the population of VM neurons, the mean locations of the peak visual and motor responses were spatially aligned. The visual response fields (RFs) were significantly smaller than and usually contained within the motor RFs. Converting RFs into the SC coordinate system significantly reduced any misalignment between peak visual and motor locations. RF size increased with increasing eccentricity in visual space but remained invariant on the SC map beyond 1 mm of the rostral pole. RF shape was significantly more symmetric in SC map coordinates compared with visual space coordinates. These results demonstrate that VM neurons specify the same location of a target stimulus in the visual field as the intended location of an upcoming saccade with minimal misalignment to downstream structures. The computational consequences of spatially transforming visual field coordinates to the SC map resulted in increased alignment and spatial symmetry during visual-sensory to saccadic-motor transformations.