Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment
Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment
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抗氧化剂预处理可防止 N-甲基-4-苯基-1,2,3,6-四氢吡啶引起的小鼠脑干中谷胱甘肽的消耗
DOI：
10.1016/0304-3940(86)90012-1
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发表时间：
1986
影响因子：
2.5
通讯作者：
A. Krisman
中科院分区：
文献类型：
--
作者：
V. Yong;T. Perry;A. Krisman
单次s.c注射n -甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP） 40 mg/kg后24 h， C57黑小鼠脑干谷胱甘肽（GSH）含量显著降低。这种GSH的损失可以通过用大量α-生育酚或β-胡萝卜素预处理动物来预防。通过膳食摄入二羟基苯丙氨酸和卡比多巴来增加小鼠黑质纹状体神经元的多巴胺周转量并没有加重MPTP的神经毒性作用。MPTP代谢物可能直接损害多巴胺能黑质纹状体神经元，而谷胱甘肽在黑质中被消耗以解毒这些代谢物。
C57 black mice showed significantly decreased glutathione (GSH) content in the brainstem 24 h after a single s.c. injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 40 mg/kg. This loss of GSH could be prevented by pretreating animals with large amounts of α-tocopherol or β-carotene. Increasing dopamine turnover of nigrostriatal neurons in mice by dietary administration ofl-dihydroxyphenylalanine and carbidopa did not accentuate the neurotoxic effects of MPTP. It seems likely that MPTP metabolites directly damage dopaminergic nigrostriatal neurons and that GSH is consumed in attempts to detoxify these metabolites in the substantia nigra.
影响因子：
6.1
作者：
CASTAGNOLI, N;CHIBA, K;TREVOR, AJ
通讯作者：
TREVOR, AJ