Type I interferons as vaccine adjuvants against infectious diseases and cancer
Type I interferons as vaccine adjuvants against infectious diseases and cancer
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DOI：
10.1586/14760584.7.3.373
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发表时间：
2008-04-01
影响因子：
6.2
通讯作者：
Proietti, Enrico
中科院分区：
文献类型：
--
作者：
Bracci, Laura;La Sorsa, Valentina;Proietti, Enrico
目前，I 型干扰素 (IFN) 作为连接先天性免疫和适应性免疫的重要因素受到了新的关注。多项研究提供了证据，证明 IFN-α 在 Th1 亚群的分化、细胞毒性 T 淋巴细胞的生成和活性、增强一抗反应和树突状细胞的激活中的重要性。由于其免疫调节特性，I 型干扰素可以代表用作疫苗接种佐剂的良好候选者。在本综述中，我们总结了最近在人类和动物模型中的研究，提出了 I 型干扰素作为佐剂的可能应用，以开发更有效的针对传染病和癌症的疫苗。
Presently, new attention is given to type I interferons (IFNs) as essential factors linking innate and adaptive immunity Several studies provided evidence about the importance of IFN-alpha in the differentiation of the Th1 subset, in the generation and activity of cytotoxic T lymphocytes, in the enhancement of a primary antibody response and in the activation of dendritic cells. Owing to their immunomodulatory properties, type I IFNs can represent good candidates to be used as adjuvants for vaccination. In the present review, we summarize recent studies in humans and in animal models, suggesting a possible application of type I IFNs as adjuvants for the development of more effective vaccines against infectious diseases and cancer.