EFFECTS OF NICOTINE ON ELECTROCORTICAL ACTIVITY AND ACETYLCHOLINE RELEASE FROM CAT CEREBRAL CORTEX
EFFECTS OF NICOTINE ON ELECTROCORTICAL ACTIVITY AND ACETYLCHOLINE RELEASE FROM CAT CEREBRAL CORTEX
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DOI：
10.1111/j.1476-5381.1969.tb07976.x
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发表时间：
1969-01-01
影响因子：
7.3
通讯作者：
SELLERS, CM
中科院分区：
文献类型：
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作者：
ARMITAGE, AK;HALL, GH;SELLERS, CM
1.在麻醉猫上研究了少量尼古丁对皮层电活动和中枢乙酰胆碱（ACh）释放的影响。2.尼古丁以2 μg/kg的剂量每30秒静脉给药一次，持续20分钟，最常见的作用是引起皮质电图去极化，表明皮质激活，皮质ACh释放增加。3.在某些实验中，给予频率较低的较大剂量（每分钟4 μg/kg，持续20分钟）导致皮质活动增加，而在其他实验中则导致皮质活动减少。这种变化分别伴随着皮质ACh输出的增加或减少。4.影响皮层电图和ACh释放的尼古丁量可能与吸烟者吸入的尼古丁量相似。5.尼古丁对皮层电图的影响是短暂的，但对ACh的影响是持久的。这表明至少有两种途径参与尼古丁反应。
1. The effects of small amounts of nicotine on electrocortical activity and central acetylcholine (ACh) release have been studied on anaesthetized cats. 2. The most common effect of nicotine given intravenously in a dose of 2 μg/kg every 30 sec for 20 min was to cause desynchronization of the electrocorticogram, indicating cortical activation, and an increase in the release of cortical ACh. 3. A larger dose given less frequently (4 μg/kg every min for 20 min) caused, in some experiments, an increase and in others a decrease in cortical activity. Such changes were accompanied respectively by an increase or decrease in cortical ACh output. 4. The amounts of nicotine that affected the electrocorticogram and ACh release are probably similar to those absorbed by the cigarette smoker who inhales. 5. The effects of nicotine on the electrocorticogram were transient, but the effects on ACh were prolonged. This suggests that at least two pathways are involved in the nicotine response.