A Ru(II)-Based Nanoassembly Exhibiting Theranostic PACT Activity in NIR Region
A Ru(II)-Based Nanoassembly Exhibiting Theranostic PACT Activity in NIR Region
复制标题
基于 Ru(II) 的纳米组件在近红外区域表现出治疗诊断 PACT 活性
DOI：
10.1002/ppsc.202000045
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发表时间：
2020
影响因子：
2.7
通讯作者：
Zhou Qianxiong
中科院分区：
文献类型：
--
作者：
Wang Youchao;Tian Na;Sun Weize;Rena Boerhan;Guo Xusheng;Feng Yang;Li Chao;Wang Xuesong;Zhou Qianxiong
Photoactivated chemotherapy (PACT) has appealing merits over traditional chemotherapy as well as photodynamic therapy (PDT) by virtue of its spatial and temporal control on drug activity and oxygen‐independent mechanisms of action. However, the short photoactivation wavelengths, e.g., visible light–activated Ru(II)‐based PACT agents, limit the clinical application severely. In this work, a facile construction of supramolecular nanoparticles from a poly(ethylene glycol) (PEG)‐modified [Ru(dip)2(py‐SO3)]+(abbreviated as Ru‐PEG, dip = 4,7‐diphenyl‐1,10‐phenanthroline, py‐SO3= pyridine‐2‐sulfonate) and 1,3‐phenylenebis(pyren‐1‐ylmethanone) (BP) is shown. While Ru‐PEG may undergo photoinduced ligand dissociation and release anticancer species of [Ru(dip)2(H2O)2]2+, BP has extremely large two‐photon absorption cross sections (δ2) in the NIR region and intense fluorescence over the wavelengths where Ru‐PEG has strong absorption. Thus, two‐photon excitation of BP followed by an efficient Förster resonance energy transfer (FRET) from BP to Ru‐PEG may lead to a potent inactivation against cisplatin‐resistant cancer cells and 3D multicellular tumor spheroids (MCTSs). The residue fluorescence of BP also allows the cellular uptake of the particles to be visualized. This work provides a universal and convenient strategy to realize theranostic PACT in the ideal phototherapeutic window of 650–900 nm.
