Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk.
Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk.
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DOI：
10.1007/978-1-59745-416-2_18
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Sellers, Thomas A
中科院分区：
文献类型：
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作者：
Park, Jong Y;Huang, Yifan;Sellers, Thomas A
前列腺癌的病因有哪些？然而，多种病因因素，包括遗传特征、类固醇激素代谢、营养、慢性炎症、前列腺癌家族史和环境暴露被认为起着重要作用。暴露于这些危险因素的变化可以解释前列腺癌风险的个体间差异。然而，无论确切的机制如何，强大的DNA修复能力都可以减轻这些风险因素突变带来的任何风险。在DNA修复基因中发现了许多单核苷酸多态性（SNP），研究这些SNP和前列腺癌风险对于了解前列腺细胞对DNA损伤的反应至关重要。DNA修复基因中的一些SNP导致前列腺癌风险显著增加，然而，在大多数情况下，这种影响是中等的，通常取决于途径中几个基因的风险等位基因之间的相互作用或与其他环境风险因素。本报告回顾了已发表的关于DNA修复途径相关基因中SNP与前列腺癌风险相关性的流行病学文献。
The specific causes of prostate cancer are not known. However, multiple etiological factors, including genetic profile, metabolism of steroid hormones, nutrition, chronic inflammation, family history of prostate cancer, and environmental exposures are thought to play significant roles. Variations in exposure to these risk factors may explain inter-individual differences in prostate cancer risk. However, regardless of the precise mechanism(s), a robust DNA repair capacity may mitigate any risks conferred by mutations from these risk factors. Numerous single nucleotide polymorphisms (SNPs) in DNA repair genes have been found, and studies of these SNPs and prostate cancer risk are critical to understanding the response of prostate cells to DNA damage. A few SNPs in DNA repair genes cause significantly increased risk of prostate cancer, however, in most cases, the effects are moderate and often depend upon interactions among the risk alleles of several genes in a pathway or with other environmental risk factors. This report reviews the published epidemiologic literature on the association of SNPs in genes involved in DNA repair pathways and prostate cancer risk.