Prospects for gene-engineered T cell immunotherapy for solid cancers.
Prospects for gene-engineered T cell immunotherapy for solid cancers.
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DOI：
10.1038/nm.4015
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发表时间：
2016-01
期刊：
影响因子：
82.9
通讯作者：
Restifo NP
中科院分区：
文献类型：
--
作者：
Klebanoff CA;Rosenberg SA;Restifo NP
受体工程T细胞的过继性转移在治疗B细胞白血病和淋巴瘤患者中产生了令人印象深刻的结果。这一成功激发了公众的想象力，并促使学术和工业研究人员开发类似的“现成”受体，针对上皮性癌症（癌症相关死亡的主要原因）的共享抗原。然而，使用这种策略成功治疗大量实体癌患者不太可能是直截了当的。受体工程T细胞有可能引起正常组织的靶上识别的致命毒性，并且在肿瘤类型之间缺乏真正的肿瘤特异性抗原。在这里，我们提出了我们的观点，即如何扩大使用基因重定向T细胞来治疗大多数实体癌患者，将需要围绕针对私人体细胞突变的自体基因疗法的发展进行重大技术、制造和监管创新。
Adoptive transfer of receptor-engineered T cells has produced impressive results in treating patients with B cell leukemias and lymphomas. This success has captured public imagination and driven academic and industrial researchers to develop similar ‘off-the-shelf’ receptors targeting shared antigens on epithelial cancers, the leading cause of cancer-related deaths. However, the successful treatment of large numbers of people with solid cancers using this strategy is unlikely to be straightforward. Receptor-engineered T cells have the potential to cause lethal toxicity from on-target recognition of normal tissues, and there is a paucity of truly tumor-specific antigens shared across tumor types. Here we offer our perspective on how expanding the use of genetically redirected T cells to treat the majority of patients with solid cancers will require major technical, manufacturing and regulatory innovations centered around the development of autologous gene therapies targeting private somatic mutations.
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DOI：
10.4049/jimmunol.1001775
发表时间：
2011-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chinnasamy N;Wargo JA;Yu Z;Rao M;Frankel TL;Riley JP;Hong JJ;Parkhurst MR;Feldman SA;Schrump DS;Restifo NP;Robbins PF;Rosenberg SA;Morgan RA
通讯作者：
Morgan RA
影响因子：
11.2
作者：
Corbiere, Veronique;Chapiro, Jacques;Coulie, Pierre G.
通讯作者：
Coulie, Pierre G.
影响因子：
15.9
作者：
Cohen, Cyrille J.;Gartner, Jared J.;Robbins, Paul F.
通讯作者：
Robbins, Paul F.
影响因子：
17.1
作者：
Brentjens RJ;Davila ML;Riviere I;Park J;Wang X;Cowell LG;Bartido S;Stefanski J;Taylor C;Olszewska M;Borquez-Ojeda O;Qu J;Wasielewska T;He Q;Bernal Y;Rijo IV;Hedvat C;Kobos R;Curran K;Steinherz P;Jurcic J;Rosenblat T;Maslak P;Frattini M;Sadelain M
通讯作者：
Sadelain M
影响因子：
45.3
作者：
Ahmed, Nabil;Brawley, Vita S.;Gottschalk, Stephen
通讯作者：
Gottschalk, Stephen